Generic Name: Casodex
What is Casodex?
Expert Opinion on Drug Safety. Prostate Cancer and Prostatic Diseases. Journal of Clinical Oncology. Prostate cancer primarily affects the elderly with 99. Prostate Cancer: New Horizons in Research and Treatment. Current Opinion in Endocrinology, Diabetes, and Obesity.
Challenges in Prostate Cancer. Nature Clinical Practice Urology. The American Journal of Case Reports. A case of near-fatal fulminant hepatic failure in a patient on bicalutamide therapy 50 mg has recently been published 101but it is uncertain whether this can be attributed to bicalutamide, as the symptoms developed after only two doses in a patient previously exposed to both cyproterone acetate and flutamide 101.
It is recommended that if bicalutamide is started in patients already receiving coumarin anticoagulants, prothrombin times should be closely monitored and adjustment of the anticoagulant dose may be necessary.
The side effects were even worse, and the Eligard cost even more than the Lupron. We have talked about changing treatments, but becasue of me being a Stage 4, they need me to have my testosterone below 20.
My doctors have all been very good at showing me every aspect of my tests. They all know that I do much research about my situation. As it turned out radioactive seeds would not have worked because of a defect where my prostate was adhered to my bladder. I was told that if I didn't go through all of the surgery, 40 Radiation treatments, and two years of Chemo Lupronmy chances of survival would be about two years.
I have no sign of spread to the bones or any where else in my body, at this time. Just one very small spot in one lymph node. My reasoning is that since we have made it this far, I want to be assured that we have done everything possible for my survival.
I want the peace of mind knowing that as often happens, the Lupron wears off after 2 - 3 years and will not control the cancer any more.
How should I take Casodex?
A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer". Drug Design, Development and Therapy. Managing Metastatic Prostate Cancer In Your Urological Oncology Practice. A recent meta-analysis relating to total androgenic blockade has shown that cyproterone acetate when combined with castration reduces the long-term efficacy of androgen-suppressive treatments.
In fact, it causes an increase in treatment-related mortality, mainly due to cardiovascular complications No authors, 2000.
What should I avoid while taking Casodex?
We applied Casodex, the current most widely used anti-androgen 13and MDV3100, a newly developed powerful anti-androgen that can delay the recurrence of increased PSA and extend PCa patient survival rate to 4. ADT with anti-androgens suppressed PCa cell growth but enhanced cell invasion. As expected, we found that the combinational treatment further suppressed cell growth Fig.
Unfortunately, the combinational therapy still failed to prevent or reverse the cell invasion induced by anti-androgen treatment Fig. Western blot analysis also showed that the expression of MMP-9, the cell invasion marker 17was increased after treatment with either anti-androgens alone or combined with PI3K-Akt inhibitor LY294002 in both CWR22Rv1 and C4-2 cells Fig.
Casodex side effects
Safety and efficacy have not been established. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of bicalutamide in the elderly.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.
Common Casodex ide effects may include:
Increased accumulation may occur in patients with moderate to severe hepatic impairment see section 4.
What other drugs could interact with this medication.
One should consume the doses as prescribed by the doctor because over dose can lead to severe side effects.
A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer".
Tan thinks that if you get castrated, then taking Casodex is not necessary. The year following this was the worst year of my life. I was 80 at the time of castration, so it was not as big a deal as it would be for a younger man.
But I will say that cutting off all your testosterone can make your quality of life very close to 0.
Where can I get more information?
Medications other than those listed above may interact with this medication.
This medication comes in tablet form and is taken once daily, with or without food.