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You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine.
If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, take it as soon as possible.
However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. For this medicine, the following should be considered:Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.
Although concomitant use of moderate CYP3A4 inhibitors with lomitapide has not been studied, a significant increase in lomitapide exposure is likely during concurrent use. Loperamide: The plasma concentration of loperamide, a CYP3A4 and P-glycoprotein P-gp substrate, may be increased when administered concurrently with diltiazem, a CYP3A4 and P-gp inhibitor.
If these drugs are used together, monitor for loperamide-associated adverse reactions, such as CNS effects and cardiac toxicities i. Lopinavir may decrease the clearance of diltiazem via inhibition of CYP3A4 metabolism. Caution is warranted and clinical monitoring of the patient is recommended.
The benefits of the use of lovastatin in patients taking diltiazem should be carefully weighed against the risks of this combination. Cutaneous vasodilation induced by niacin may become problematic if high-dose niacin is used concomitantly with other antihypertensive agents, especially calcium-channel blockers. Diltiazem is a substrate and moderate inhibitor of both CYP3A4 and P-glycoprotein P-gp. Coadministration of diltiazem and rifampin, a strong CYP3A inducer, resulted in undetectable diltiazem plasma concentrations.
Lurasidone: Diltiazem is a moderate inhibitor of CYP3A4 and has the potential for interactions with substrates of CYP3A4 such as lurasidone.
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Diltiazem and verapamil are substrates and inhibitors of CYP3A4. Mild to moderate increases in haloperidol plasma concentrations have been reported during concurrent use of haloperidol and substrates or inhibitors of CYP3A4 or CYP2D6. Elevated haloperidol concentrations occurring through inhibition of CYP2D6 or CYP3A4 may increase the risk of adverse effects, including QT prolongation. Hawthorn may also lower peripheral vascular resistance. Patients with hypertension or heart failure should be advised to only use hawthorn with their prescribed medications after discussion with their prescriber.
Patients who choose to take hawthorn should receive periodic blood pressure and heart rate monitoring.
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High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks.
These problems may be less likely to occur if blood pressure is controlled. Diltiazem is a calcium channel blocker.
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It is believed that diltiazem decreases renal and nonrenal clearance of digoxin. In addition, digoxin is a substrate for P-glycoprotein P-gp and diltiazem is both a substrate and an inhibitor of P-gp.
Measure serum digoxin concentrations before initiating diltiazem. Despite the potential for interactions, digoxin sometimes is intentionally used in combination with diltiazem to further reduce conduction through the AV node. Nevertheless, these combinations should be used cautiously, and close monitoring of serum digoxin concentrations is essential to avoid enhanced toxicity.
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Trabectedin: Use caution if coadministration of trabectedin and diltiazem is necessary, due to the risk of increased trabectedin exposure.
Concomitant use may increase the plasma concentration of ulipristal resulting in an increased risk for adverse events.
The dosage can also be decreased if you experience bothersome side effects of Cartia XT.
Doing so can release all of the drug at once and may increase your risk of side effects.
Valid as of June 25, 2017 Click the "Get free coupon" button to receive your free Cartia Xt discount Print, email or text message your coupon Present your coupon the next time you fill your prescription Cartia XT is used to treat high blood pressure and to control angina, and it is in a class of medications called calcium-channel blockers.
Cartia XT works by relaxing the blood vessels and helps to lower your heart rate. This medication also helps to increase the supply of blood and oxygen to the heart so the heart does not have to pump as hard. High blood pressure is a common condition, and when not treated it can cause damage to the brain, heart, blood vessels, kidneys, and other parts of the body.
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Bortezomib: Patients on antihypertensive agents receiving bortezomib treatment may require close monitoring of their blood pressure and dosage adjustment of their medication.
Patients with hypertension or heart failure should be advised to only use hawthorn with their prescribed medications after discussion with their prescriber.