Generic Name: Generic cardura
What is Generic Cardura?
Cardura is appropriate for oral administration in a once daily regimen in patients with essential hypertension. Cardura has been shown to be free of adverse metabolic effects and is suitable for use in patients with coexistent diabetes mellitus, gout and insulin resistance. Cardura is suitable for use in patients with co-existent asthma, left ventricular hypertrophy and in elderly patients.
Treatment with Cardura has been shown to result in regression of left ventricular hypertrophy, inhibition of platelet aggregation and enhanced activity of tissue plasminogen activator. Additionally, Cardura improves insulin sensitivity in patients with impairment.
Cardura, in addition to its antihypertensive effect, has in long term studies produced a modest reduction in plasma total cholesterol, LDL-cholesterol and triglyceride concentrations and therefore may be of particular benefit to hypertensive patients with concomitant hyperlipidaemia.
Administration of Cardura to patients with symptomatic BPH results in a significant improvement in urodynamics and symptoms. The effect in BPH is thought to result from selective blockade of the alpha-adrenoceptors located in the muscular stroma and capsule of the prostate, and in the bladder neck.
Absorption: Following oral administration in humans young male adults or the elderly of either sexdoxazosin is well absorbed and approximately two thirds of the dose is bioavailable. Doxazosin is extensively metabolised in man and in the animal species tested, with the faeces being the predominant route of excretion.
The mean plasma elimination half-life is 22 hours thus making the drug suitable for once daily administration.
Experience with CARDURA overdosage is limited. Two adolescents, who each intentionally ingested 40 mg CARDURA with diclofenac or acetaminophen, were treated with gastric lavage with activated charcoal and made full recoveries.
A two-year-old child who accidently ingested 4 mg CARDURA was treated with gastric lavage and remained normotensive during the five-hour emergency room observation period. A six-month-old child accidentally received a crushed 1 mg tablet of CARDURA and was reported to have been drowsy. The most likely manifestation of overdosage would be hypotension, for which the usual treatment would be intravenous infusion of fluid.
As doxazosin is highly protein bound, dialysis would not be indicated. The use of CARDURA is contraindicated in patients with a hypersensitivity to doxazosin, other quinazolines e. The symptoms associated with benign prostatic hyperplasia BPHsuch as urinary frequency, nocturia, weak stream, hesitancy, and incomplete emptying are related to two components, anatomical static and functional dynamic. Studies in normal human subjects have shown that doxazosin competitively antagonized the pressor effects of phenylephrine an alpha1 agonist and the systolic pressor effect of norepinephrine.
Doxazosin and prazosin have similar abilities to antagonize phenylephrine. The antihypertensive effect of CARDURA results from a decrease in systemic vascular resistance. The parent compound doxazosin is primarily responsible for the antihypertensive activity. The low plasma concentrations of known active and inactive metabolites of doxazosin 2-piperazinyl, 6'-and 7'-hydroxy and 6-and 7-O-desmethyl compounds compared to parent drug indicate that the contribution of even the most potent compound 6'-hydroxy to the antihypertensive effect of doxazosin in man is probably small.
Although blockade of alpha1 adrenoceptors also lowers blood pressure in hypertensive patients with increased peripheral vascular resistance, CARDURA treatment of normotensive men with BPH did not result in a clinically significant blood pressure lowering effect Table 4.
How should I take Generic Cardura?
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What should I avoid while taking Generic Cardura?
How should I take doxazosin Cardura, Cardura XL. What happens if I miss a dose Cardura, Cardura XL. What happens if I overdose Cardura, Cardura XL. What should I avoid while taking doxazosin Cardura, Cardura XL. What other drugs will affect doxazosin Cardura, Cardura XL. Where can I get more information.
What is doxazosin Cardura, Cardura XL.
Generic Cardura side effects
It is also used alone or in combination with other medications to treat high blood pressure. Doxazosin is in a class of medications called alpha-blockers. It relieves the symptoms of BPH by relaxing the muscles of the bladder and prostate. It lowers blood pressure by relaxing the blood vessels so that blood can flow more easily through the body. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body.
Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems.
Common Generic Cardura ide effects may include:
Keep taking the medication even if you feel well.
Doxazosin oral tablet is sedating and causes drowsiness.
Talk to your doctor or pharmacist about lifestyle changes that might benefit you.
With once daily dosing, clinically significant reductions in blood pressure are present throughout the day and at 24 hours post dose.
In Tennessee, GoodRx is registered as a Prescription Drug Discount Plan Operator. Server Error A server error occured, please refresh the page and try again We apologize for the inconvenience Average Cash Price GoodRx Fair Price. Updated January 12, 2017If you are a consumer or patient please visit this version. CARDURA XL is an alpha1 adrenergic antagonist indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia.
Where can I get more information?
This drug may be used as part of a combination therapy.
Accordingly, during pregnancy, Cardura XL should be used only when, in the opinion of the physician, the potential benefit outweighs the potential risk.