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Use in Patients Undergoing Cataract Surgery: Intraoperative Floppy Iris Syndrome The 'intraoperative floppy iris syndrome' IFIS, a variant of small pupil syndrome has been observed during cataract surgery in some patients on or previously treated with tamsulosin.
Use during lactation: Doxazosin is contraindicated during lactation as animal studies have shown that doxazosin accumulates in milk of lactating rats, and there is no information about the excretion of the drug into the milk of lactating women.
Use during breast-feeding: Alternatively, mothers should stop breast-feeding when treatment with doxazosin is necessary see section 5. Go to top of the page5. The pharmacokinetic characteristics of Cardura XL will lead to a smoother plasma profile.
Cardura is indicated for the treatment of hypertension and can be used as a sole agent to control blood pressure in hypertensive patients. Cardura is indicated as an adjunct in the treatment of urinary outflow obstruction and symptoms associated with benign prostatic hyperplasia BPH. It may therefore be of value in patients awaiting prostatic surgery or for whom surgery is not possible.
Adults: Cardura is used in a once daily regimen and may be administered in the morning or evening. The dosage may then be increased to 2 mg once daily for an additional one or two weeks.
If necessary the daily dosage should then be increased gradually at similar intervals to 4 mg, 8 mg, and l6 mg as determined by patient response to achieve the desired reduction in blood pressure.
Senior Dosage ages 65 years and older Your body may process this drug more slowly. Based on your blood pressure, your doctor may increase your dose 2 mg at a time to a maximum dose of 16 mg per day. Never try to catch up by taking two doses at once.
This could result in toxic side effects How to Tell If the Drug Is Working: You may be able to tell this drug is working for benign prostatic hyperplasia BPH if you have an easier time urinating and experience fewer symptoms of obstruction and irritation.
You can cut or crush the immediate-release tablet. Not every pharmacy stocks this drug, so call ahead. Refill A prescription for this medication is refillable. Travel When traveling with your medication: Always carry it with you or in your carry-on bag. Keep the original prescription-labeled box with you when traveling. Insurance Many insurance companies will require a prior authorization before they approve the prescription and pay for doxazosin.
Advertisement There are other drugs available to treat your condition. Talk to your doctor about possible alternatives Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date.
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This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www. By reporting side effects you can help provide more information on the safety of this medicine. Other supportive measures may be appropriate in individual cases.
If this measure is inadequate, shock should first be treated with volume expanders.
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No studies have been conducted with Cardura XL. However, the theoretical potential for interaction with other protein bound drugs should be borne in mind. In vitro studies suggest that doxazosin is a substrate of cytochrome P450 3A4 CYP 3A4. Caution should be exercised when concomitantly administering doxazosin with a strong CYP 3A4 inhibitor, such as clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, or voriconazole see section 5.
Conventional doxazosin has been administered without any adverse drug interactions in clinical experience with thiazide diuretics, furosemide, beta-blocking agents, non-steroidal anti-inflammatory drugs, antibiotics, oral hypoglycaemic drugs, uricosuric agents, or anticoagulants.
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All practitioners must educate patients about their medications so that they are completely familiar with each product's name brand and genericpurpose, and expected appearance.
Since there is no clinical experience in patients with severe hepatic impairment, use in these patients is not recommended.
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The incidence of hypotension with CARDURA XL use appears to be age related and more prevalent in patients 70 years or older.
In these two studies, the cumulative incidence of hypotension appeared to be age related. Since there is no clinical experience in patients with severe hepatic impairment, use in these patients is not recommended. There is no experience with CARDURA XL overdosage.
A six-month-old child accidentally received a crushed 1 mg tablet of doxazosin IR and was reported to have been drowsy.
Where can I get more information?
After oral administration of doxazosin the plasma concentrations of the metabolites are low.
If you miss your doses for several days in a row, call your doctor before restarting the medication.