Generic Name: Calan
What is Calan?
Verapamil is classified in FDA pregnancy risk category C. Verapamil crosses the placenta and can be detected in umbilical vein blood at delivery. Although verapamil has been shown to have deleterious effects on fetal growth and development in animal studies, it is not known if verapamil is teratogenic. No adequate or well-controlled studies have been performed in humans: use of verapamil during pregnancy should be restricted to cases where therapeutic benefits outweigh the potential risk to the fetus.
Verapamil distributes into breast milk, and the manufacturers of verapamil products generally recommend discontinuation of breast-feeding during verapamil administration. The neonatal myocardium is very sensitive to changes in calcium status, and the therapeutic dose for a neonate is unknown. If a breast-feeding infant experiences an adverse effect related to a maternally ingested drug, healthcare providers are encouraged to report the adverse effect to the FDA.
Use of verapamil in neonates and infants should generally be avoided. Children are also more likely than adults to be susceptible to the hemodynamic effects of verapamil. Safe and effective use of conventional and extended-release verapamil tablets in children younger than 18 years of age has not been established. In general, lower initial doses of verapamil may be warranted in geriatric patients.
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It works by relaxing the muscles of your heart and blood vessels. Verapamil is used to treat hypertension high blood pressureangina chest painand certain heart rhythm disorders. This is not a complete list of side effects and others may occur. You may report side effects to FDA at 1-800-FDA-1088.
How should I take Calan?
Meclofenamate Sodium: If nonsteroidal anti-inflammatory drugs NSAIDs and an antihypertensive drug are concurrently used, carefully monitor the patient for signs and symptoms of renal insufficiency and blood pressure control.
Mefenamic Acid: If nonsteroidal anti-inflammatory drugs NSAIDs and an antihypertensive drug are concurrently used, carefully monitor the patient for signs and symptoms of renal insufficiency and blood pressure control. Mefloquine: Mefloquine is metabolized by CYP3A4. Verapamil is an inhibitor of this enzyme and may decrease the clearance of mefloquine and increase mefloquine systemic exposure. Melatonin: Melatonin may impair the efficacy of some calcium-channel blockers, and caution is advised with concurrent use.
What should I avoid while taking Calan?
Coadministration of alprazolam, a CYP3A4 substrate, with verapamil, a moderate CYP3A4 inhibitor, may result in increased alprazolam exposure. Alprostadil: The concomitant use of systemic alprostadil injection and antihypertensive agents, like calcium channel blockers, may cause additive hypotension. Caution is advised with this combination.
Systemic drug interactions with the urethral suppository MUSE or alprostadil intracavernous injection are unlikely in most patients because low or undetectable amounts of the drug are found in the peripheral venous circulation following administration.
In those men with significant corpora cavernosa venous leakage, hypotension might be more likely. Use caution with in-clinic dosing for erectile dysfunction ED and monitor for the effects on blood pressure. Although the concomitant use of mild to moderate inhibitors of P-gp did not influence the pharmacokinetics of alvimopan, the concomitant use of strong P-gp inhibitors, such as verapamil has not been studied.
Calan side effects
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Common Calan ide effects may include:
Amifostine: Patients receiving calcium-channel blockers should be closely monitored during amifostine infusions due to additive effects.
Monitor patients closely for alpha-adrenergic effects including hypotension, drowsiness, lethargy, and bradycardia.
If these drugs are coadministered, patients should be monitored for increased toxicity as well as increased therapeutic effect of alvimopan.
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Verapamil ER is an extended-release form of verapamil that is used to treat high blood pressure. The prescribing information does not specifically list enlarged aorta as a possible long-term side effect of verapamil use.
The aorta is the large blood vessel that comes out of the heart to deliver blood to the body. The aorta can become enlarged at any point over its 2- to 3-foot length.
Enlargement of the aorta is generally caused by conditions that change the properties of the blood vessel wall.
More about Calan
Other brands:Cheap reminyl
Where can I get more information?
Close The dose of verapamil must be individualized by titration.
Methysergide: Because of the potential to cause coronary vasospasmmethysergide theoretically could antagonize the therapeutic effects of calcium-channel blockers.