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This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: aliskiren, clonidine, disopyramide, dofetilide, dolasetron, fingolimod, lithium.
Other medications can affect the removal of verapamil from your body, which may affect how verapamil works. Examples of affected drugs include asunaprevir, colchicine, flibanserin, ivabradine, lomitapide, midazolam, triazolam, among others. Some products have ingredients that could raise your heart rate or blood pressure.
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Keep all medical and lab appointments. Check your blood pressure and pulse heart rate regularly while taking this medication.
Learn how to check your own blood pressure and pulse at home, and share the results with your doctor. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose.
Edoxaban is a P-glycoprotein P-gp substrate and verapamil is a P-gp inhibitor. No data are available regarding coadministration of efavirenz with other calcium channel blockers that are CYP3A4 substrates e. Verapamil is a substrate and moderate inhibitor of CYP3A. Both elbasvir and grazoprevir are metabolized by CYP3A, and grazoprevir is also a weak CYP3A inhibitor. If these drugs are used together, closely monitor for signs of hepatotoxicity.
Eletriptan: Eletriptan is contraindicated for use within 72 hours of usage of any drug that is a potent CYP3A4 inhibitor. Eletriptan is metabolized via the hepatic cytochrome P-450 CYP 3A4 and verapamil is a potent CYP3A4 inhibitor. Concomitant use of verapamil and eletriptan resulted in a 2-fold increase in the Cmax and about a 3-fold increase in the AUC of eletriptan. In addition, eletriptan may reduce the effectiveness of antihypertensive agents. Increased blood pressure may be an adverse effect of eletriptan, and the drug is contraindicated for use in patients with uncontrolled hypertension.
Patients on antihypertensives need to have their blood pressure adequately controlled if they are to receive eletriptan. If eletriptan is used, regular blood pressure monitoring is recommended.
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Small clinical trials have indicated that the coadministration of r-verapamil, an isomer of verapamil, and paclitaxel results in a significant decrease in paclitaxel clearance and an increase in paclitaxel toxicity. Some experts state that pharmacokinetic interactions between paclitaxel and verapamil do not appear to be clinically significant in vivo.
Paliperidone: Paliperidone may cause orthostatic hypotension and thus enhance the hypotensive effects of antihypertensive agents. Lower initial doses of paliperidone may be necessary in patients receiving antihypertensive agents concomitantly.
Paricalcitol: Paricalcitol is partially metabolized by CYP3A4. Care should be taken when dosing paricalcitol with strong CYP3A4 inhibitors, such as verapamil. Dose adjustments of paricalcitol may be required.
Monitor plasma PTH and serum calcium and phosphorous concentrations if a patient initiates or discontinues therapy with this combination.
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Rilpivirine: Close clinical monitoring is advised when administering verapamil with rilpivirine due to an increased potential for rilpivirine-related adverse events.
Risperidone: Risperidone may induce orthostatic hypotension and thus enhance the hypotensive effects of antihypertensive agents. Lower initial doses or slower dose titration of risperidone may be necessary in patients receiving antihypertensive agents concomitantly. Ritonavir: Concurrent administration of verapamil with ritonavir may result in elevated plasma concentrations of both drugs. Rituximab: Patients should not take antihypertensive agents 12 hours prior to rituximab infusions due to the possibility of hypotension occurring during the rituximab infusion.
Verapamil is a moderate CYP3A4 inhibitor and P-glycoprotein P-gp inhibitor. Pharmacokinetic data from a trial with erythromycin indicate that concurrent use of rivaroxaban and drugs that are combined P-gp inhibitors and moderate CYP3A4 inhibitors in patients with renal impairment results in increased exposure to rivaroxaban compared to patients with normal renal function and no inhibitor use.
Significant increases in rivaroxaban exposure may increase bleeding risk.
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For details on how to send in your prescription, Click Here lang. A: Grapefruit, grapefruit juice and certain types of oranges can inhibit the metabolism breakdown of certain medications, such as verapamil.
When the metabolism is inhibited this can cause higher levels of the medication in the body and potentially dangerous side effects. You may want to discuss the use of grapefruit with your doctor while being treated with verapamil. For additional information regarding verapamil, you may want to visit our website.
Patients on verapamil should contact their health care provider right away for any rapid weight gain or swelling of the hands, feet, or ankles.
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Quick GuideHow to Lower Blood Pressure: Exercise Tips Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA.
Vemurafenib: Concomitant use of vemurafenib and verapamil may result in altered concentrations of verapamil and increased concentrations of vemurafenib.
The serum concentration of Dihydrotestosterone can be decreased when it is combined with Verapamil.
Penbutolol: Oral calcium-channel blockers and beta-blockers like penbutolol are used together for their therapeutic benefits to reduce angina and improve exercise tolerance.
Monitor patients for signs and symptoms of venetoclax toxicity such as hematologic toxicity, GI toxicity, and tumor lysis syndrome. Vilazodone: Because CYP3A4 is the primary isoenzyme involved in the metabolism of vilazodone, concurrent use of a moderate inhibitor of CYP3A4 such as verapamil may decrease the clearance of vilazodone. Concurrent use of vilazodone and verapamil may lead to an increased risk of vilazodone-related adverse reactions. The manufacturer recommends that the daily dose of vilazodone be reduced to 20 mg in patients who experience intolerable side effects while receiving moderate inhibitors of CYP3A4.
Vinblastine: Verapamil is an inhibitor of the efflux transporter P-glycoprotein Pgp, ABCB1 and an inhibitor of cytochrome P450 CYP isoenzyme 3A4.
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It should not be used for medical advice, diagnosis or treatment.
The risk or severity of adverse effects can be increased when Tioconazole is combined with Verapamil.