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Fractures are only a consequence of bone fragility brought about by osteoporosis. These occur only after the disease has progressed long enough. Thus, most people do not know they have the disease until the first fracture develops. Though a strong impact or injury is necessary to cause a fracture on the bone, osteoporotic fractures are different. Osteoporosis causes the bone to become significantly weak and porous, that minor trauma or sometimes no trauma at all can cause fractures.
To make an accurate diagnosis of osteoporosis, it is necessary to determine the bone mineral density BMD of a patient. A dual-emmision x-ray absorptiometry or DXA is used for this purpose. According to the World Health Organization, low bone mass is defined as having bone mineral density of 2. Aside from BMD, other indicative factors include bone fracture xray, family history and heightloss due to vertebral fracture. Normally, the bone is under homeostatic balance of continuous resorption by osteoclasts, and formation by osteoblasts.
These cells are regulated by several hormones - parathyroid hormone PTH promotes resoption while calcitonin and estrogen promote bone formation. In osteoporosis, there is excessive bone loss, which is usually caused by excessive bone resorption activity by osteoclasts.
June 2010 issue of More magazine has an excellent article on this. Some doctors are recommending alternative medications if a patient is in her fifties than if she is in her eighties. Preventing that population from obtaining them is tentamount to refusing a vaccine to the population who needs it because a small population suffers from severe side effects.
I am genetically predisposed to osteo but I am too young to take this drug, based on all the research I have to date. Individuals need to be proactive about researching their own situation and work with a doctor who is open minded and up on modern study results. I took Boniva for five years the first two years no problems but into the third year I noticed that my joints were really aching and my thigh bone felt like the muscle was pulling away from it.
I thought at the time it was arthritis but I have now been off of the Boniva for three years and the joint pain I had has stopped even the problem with my thigh has gone away.
I really think it was the Boniva that was causing my problems. There were times that I could not get up off the floor if I sat down on it because my joints hurt so bad. Now I get up and down with little trouble of course not like I did when I was in my twenties as I am 66 years old now but I can still get up without the help of someone.
I tripped and fell into my cabinits last Sept and all my weight and I was 25 lbs.
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Now that I finally went to a bone Doc, she prescribed actonel. I was going to have the prescription filled, but I was very unsure of it helping. Thanks to you, I will NOT be taking it. I recommend that you consult with a nutritional therapist such as a Nutritional Therapy Practitioner or a holistic physician to evaluate how best to get the nutrients you need from your diet.
I just read the recipe for bone broth- which is basically homemade chicken soup. I buy chicken bones, which is the carcass of the chicken taken off, but is mostly bones.
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While osteoporosis occurs in both men and women, it is most common among women following menopause. In postmenopausal osteoporosis, bone resorption exceeds bone formation, leading to bone loss and increased risk of fracture.
BONIVA produced biochemical changes indicative of dose-dependent inhibition of bone resorption, including decreases of biochemical markers of bone collagen degradation such as deoxypyridinoline, and cross-linked C-telopeptide of Type I collagen in the daily dose range of 0. Changes in markers of bone formation were observed later than changes in resorption markers, as expected, due to the coupled nature of bone resorption and formation. Following treatment discontinuation, there is a return to pretreatment baseline rates of elevated bone resorption associated with postmenopausal osteoporosis.
The extent of absorption is impaired by food or beverages other than plain water.
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There were equal numbers of women in both placebo and treatment groups with this symptom meaning that ibandronate does not cause it any more often than placebo does. Treat hypocalcemia, hypovitaminosis D, and other disturbances of bone and mineral metabolism before starting Boniva Injection therapy.
Adequate intake of calcium and vitamin D is important in all patients. It is recommended that patients receive supplemental calcium and vitamin D if dietary intake is inadequate. Although no cases of acute renal failure were observed in controlled clinical trials in which intravenous Boniva was administered as a 15- to 30-second bolus, acute renal failure has been reported postmarketing.
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As a result, doctors warn patients to have needed dental work done well before going on the medication, and observing strict oral hygiene after taking it.
You may also report side effects to Genentech at 1-888-835-2555.
Then I went on Boniva and got severe bone pain in my long bones of the leg.
I am not a health practitioner, but if I were faced with your decision I would try nutritional solutions for a few months before using drugs.
In multiple myeloma animal models, ibandronate inhibited osteoclast stimulatory activity and the development of lytic lesions, but not eventual tumor burden. Inhibition of enzymes in the mevalonate pathway appears to explain the effectiveness of ibandronate in multiple myeloma.
It is expected that, like other bisphosphonates, ibandronate decreases the extent of accelerated bone resorption that results from osteoclast hyperactivity. Ibandronate does not lower the level of parathyroid hormone-related protein PTHrP in patients with hypercalcemia of malignancy. Ibandronate inhibits bone resorption without inhibiting bone formation or mineralization.
Where can I get more information?
In January 2008, the FDA warned that use of bisphosphonates had been linked to severe and sometimes incapacitating bone, joint, and muscle musculoskeletal pain.
Some recommend that divalent cation-containing products should preferentially be taken at least 2 hours after these drugs or at a different time of day.