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During the first four weeks of therapy, while patients were maintained on their originally assigned dose, there were 11 deaths in 255 patients taking 500 mg b. The adverse event profiles showed that both the 500 and 1000 mg b. The 2000 mg b. In AIDS patients and other immunocompromised patients treated with the higher doses of clarithromycin over long periods of time for mycobacterial infections, it was often difficult to distinguish adverse events possibly associated with clarithromycin administration from underlying signs of HIV disease or intercurrent illness.
The following analyses summarize experience during the first 12 weeks of therapy with clarithromycin. Data are reported separately for Study 500 randomized, double-blind and Study 577 open-label, compassionate use and also combined. Adverse events were reported less frequently in Study 577, which may be due in part to differences in monitoring between the two studies. In adult patients receiving clarithromycin 500 mg b. Overall, the 500 and 1000 mg b. A limited number of pediatric AIDS patients have been treated with clarithromycin suspension for mycobacterial infections.
The most frequently reported adverse events, excluding those due to the patient's concurrent condition, were consistent with those observed in adult patients.
You should not use this medication if you have a life-threatening heart rhythm disorder, a history of Long QT syndrome, if you have ever had jaundice or liver problems caused by taking clarithromycin, or if you have liver or kidney disease and are also taking colchicine Colcrys.
Do not use clarithromycin if you are also using any of the drugs listed below. They can interact with clarithromycin and cause serious or life-threatening side effects:Take this medicine for the full prescribed length of time. Clarithromycin will not treat a viral infection such as the common cold or flu. Facebook Twitter Email Print Article You are about to visit a website outside of eMedicineHealth. ContinueYou are about to visit a website outside of eMedicineHealth.
ContinuePRINT From Infectious Disease Resources 8 Serious HIV Symptoms to Watch For Is It a Cold, Strep, or Tonsillitis. What should I discuss with my healthcare provider before taking clarithromycin Biaxin, Biaxin XL, Biaxin XL-Pak. How should I take clarithromycin Biaxin, Biaxin XL, Biaxin XL-Pak. What happens if I miss a dose Biaxin, Biaxin XL, Biaxin XL-Pak.
What happens if I overdose Biaxin, Biaxin XL, Biaxin XL-Pak. What should I avoid while taking clarithromycin Biaxin, Biaxin XL, Biaxin XL-Pak.
What other drugs will affect clarithromycin Biaxin, Biaxin XL, Biaxin XL-Pak. Where can I get more information. What is clarithromycin Biaxin, Biaxin XL, Biaxin XL-Pak.
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Clarithromycin may cause a serious condition known as QT prolongation, causing a change in the heart rhythm. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may affect the heart rhythm. This risk may increase if you use diuretics "water pills". Severe sweating, diarrhea, or vomiting can also increase your risk of QT prolongation.
Clarithromycin should be avoided for people receiving certain heart medications. Talk to your doctor if you receive medications for irregular heart rate, or if you have any other heart condition.
When certain bacteria grow too rapidly in the colon, this serious condition can occur. Tell your doctor if you experience bloody, watery diarrhea.
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In these trials, strict evaluability criteria were used to determine the clinical responses. In the 233 patients who were evaluated for clinical efficacy, the combined clinical success rate i. Two trials trials 9 and 10 were conducted in patients with an active duodenal ulcer, and the third trial trial 11 was conducted in patients with a duodenal ulcer in the past 5 years, but without an ulcer present at the time of enrollment.
The dosage regimen in the trials was Biaxin 500 mg twice a day plus omeprazole 20 mg twice a day plus amoxicillin 1 gram twice a day for 10 days. In trials 9 and 10, patients who took the omeprazole regimen also received an additional 18 days of omeprazole 20 mg once a day. Trials 12 and 13 were conducted in the U.
These trials compared the combination regimen to omeprazole and Biaxin monotherapies.
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Skip to Main Content U. National Library of Medicine U. Download DRUG LABEL INFO: PDF XML Official Label Printer Friendly View All SectionsClose All Sections To reduce the development of drug-resistant bacteria and maintain the effectiveness of BIAXIN and other antibacterial drugs, BIAXIN should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
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For pneumonia, the use of clarithromycin oral suspension has not been studied for children younger than 3 years of age.
While gene probe techniques may be used to distinguish M.
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For treatment and prophylaxis of mycobacterial infections in adults, the recommended dose of BIAXIN is 500 mg every 12 hours.
Clarithromycin will not treat a viral infection such as the flu or a common cold. Take the missed dose as soon as you remember. If you have diarrhea that is watery or bloody, stop taking clarithromycin and call your doctor. Many drugs can interact with clarithromycin.
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If your CD4 cell count is below 50, talk to your health care provider about using clarithromycin.
Do not take extra medicine to make up the missed dose.