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This is only a brief summary of general information about Betapace. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Betapace. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Betapace.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine.
You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
In rabbits, a dose of sotalol 6 times the MRHD produced a slight increase in fetal death as well as maternal toxicity. This effect did not occur at sotalol dose 3 times the MRHD. In rats a sotalol dose 18 times the MRHD increased the number of early resorptions, while a dose 2. Sotalol is excreted in the milk of laboratory animals and has been reported to be present in human milk. The safety and effectiveness of sotalol in children have not been established.
Sotalol is mainly eliminated via the kidneys. The most common signs to be expected are bradycardia, congestive heart failure, hypotension, bronchospasm and hypoglycemia. In cases of massive intentional overdosage 2-16 grams of sotalol the following clinical findings were seen: hypotension, bradycardia, cardiac asystole, prolongation of QT interval, Torsade de Pointes, ventricular tachycardia, and premature ventricular complexes.
If overdosage occurs, therapy with sotalol should be discontinued and the patient observed closely. Because of the lack of protein binding, hemodialysis is useful for reducing sotalol plasma concentrations. The occurrence of hypotension following an overdose may be associated with an initial slow drug elimination phase half-life of 30 hours thought to be due to a temporary reduction of renal function caused by the hypotension.
Sotalol has both beta-adrenoreceptor blocking Vaughan Williams Class II and cardiac action potential duration prolongation Vaughan Williams Class III antiarrhythmic properties.
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Betapace tablets must be taken by mouth with water. It can be taken once or twice a day and it is typically taken on an empty stomach. An individual taking this medication is advised to take it on the same time every day to keep track of medical condition.
However, the dosage of Betapace depends on the age, medical history and reaction of the person to the treatment. You should be very careful while taking the liquid formulation of this medication as it is easy to overdose when it is in the form of liquid.
All these instructions will be given in detail when you consult a physician. When Betapace is overdosed or not taken in the right form there are more possibilities for side effects like dizziness, headache, lightheadedness, fatigue and diarrhea. One should stop taking the medication and consult the physician immediately when they experience side effects like chest pain, palpitations rapid heartbeat due to illness or bradycardia abnormally slow heart rate.
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Examples of these medications include: glipizide glyburide Drugs to improve breathing Taking sotalol with certain drugs to improve your breathing can make them less effective.
Examples of these drugs include: albuterol terbutaline isoproterenol Certain antacids Avoid taking sotalol within 2 hours of taking certain antacids. These antacids are those that contain aluminum hydroxide and magnesium hydroxide, such as: Mylanta Mag-al Mintox cisapride gastrointestinal reflux disease drug Mental health drugs Combining certain mental health drugs with sotalol may make your heart condition worse or lead to a serious heart rhythm problem called torsades de pointes.
Examples of these drugs include: thioridazine pimozide ziprasidone tricyclic antidepressants such as amitriptyline, amoxapine, or clomipramine Antibiotics Combining certain antibiotics with sotalol can make your heart condition worse. Examples of these drugs include: oral macrolides such as erythromycin or clarithromycin quinolones such as ofloxacin, ciprofloxacin, or levofloxacin Disclaimer: Our goal is to provide you with the most relevant and current information.
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ActionBlocks stimulation of cardiac beta1-adrenergic and pulmonary, vascular, and uterine beta2-adrenergic receptor sites. Adverse reactionsCNS: fatigue, weakness, anxiety, dizziness, drowsiness, insomnia, memory loss, depression, mental status changes, nervousness, paresthesia, nightmaresCV: orthostatic hypotension, peripheral vasoconstriction, bradycardia, arrhythmias, heart failure, AV blockEENT: blurred vision, dry eyes, nasal stuffinessGI: nausea, constipation, diarrheaGU: erectile dysfunction, decreased libidoMetabolic: hyperglycemia, hypoglycemiaMusculoskeletal: joint pain, back pain, muscle crampsRespiratory: wheezing, bronchospasmSkin: itching, rashOther: lupus syndrome, hypersensitivity reactionInteractionsDrug-drug.
Amphetamines, ephedrine, epinephrine, norepinephrine, phenylephrine, pseudoephedrine: unopposed alpha-adrenergic stimulation, causing excessive hypotension and bradycardiaBeta-adrenergic bronchodilators, theophylline: decreased efficacy of these drugsCalcium channel blockers: increased risk of adverse cardiovascular reactionsClass IA antiarrhythmics such as amiodarone, quinidine : increased risk of arrhythmiasClonidine: excessive rebound hypertension with clonidine withdrawalErgot alkaloids: peripheral ischemia or gangreneGeneral anesthestics, phenytoin I.
References in periodicals archive. Sotalol Hydrochloride Tablets USP AF are the generic version of Berlex Inc. Mylan Announces Final FDA Approval for Sotalol Hydrochloride Tablets, USP AF Sotalol Hydrochloride is the generic equivalent to Berlex Laboratories' Betapace Rwhich is indicated for the treatment of documented, life-threatening ventricular arrhythmia.
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Survival With Oral d-Sotalol.
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Back to Top Seek emergency medical attention if you have taken more sotalol than was prescribed.
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