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In this article we'll be looking at the effectiveness of Bactrim also available in double strength, known as Bactrim DSan oral antibiotic, in treating a sinus infection. Common symptoms of a sinus infection include a runny nose, a negatively affected sense of smell, painful pressure in the sinuses, watery eyes and a fever.
There are over the counter medications that are effective at treating these symptoms individually, but in order to treat the infection itself, an antibiotic is usually prescribed by a medical professional. If either of these scenarios comes up, then a doctor may prescribe Bactrim. Bactrim, a combination antibiotic which contains trimethoprim and sulfamethoxazole, is known to be effective against a number of infections, and even treatment-resistent bacteria such as MRSA.
Also, many people who happen to be allergic to or have negative reactions to other antibiotics such as Amoxicillin are usually able to take Bactrim without any side effects or negative reactions. Despite its effectiveness, however, Bactrim is not as commonly prescribed for sinusitis as other more common antibiotics.
Instead, it is usually used for traveler's diarrhea, urinary tract infections, bronchitis, pneumonia and a few other types of bacterial infections. However, if you do wish to take Bactrim to treat a sinus infection, there general length of a course of Bactrim treatment is ten days, but can sometimes range from five to fourteen days, depending on the type and severity of the infection.
As with any antibiotic, it is very important to take it every single day for the duration of the course, and see the course through completely. Stopping halfway through or skipping days could result in some bacteria surviving the treatment, and the infection becoming even worse.
Peak blood levels for the individual components occur 1 to 4 hours after oral administration. The mean serum half-lives of sulfamethoxazole and trimethoprim are 10 and 8 to 10 hours, respectively. Detectable amounts of sulfamethoxazole and trimethoprim are present in the blood 24 hours after drug administration.
During administration of 800 mg sulfamethoxazole and 160 mg trimethoprim b. The steady-state mean plasma levels of free and total sulfamethoxazole were 57. These steady-state levels were achieved after three days of drug administration. Urine concentrations of both sulfamethoxazole and trimethoprim are considerably higher than are the concentrations in the blood.
The average percentage of the dose recovered in urine from 0 to 72 hours after a single oral dose of sulfamethoxazole and trimethoprim is 84. Thirty percent of the total sulfonamide is excreted as free sulfamethoxazole, with the remaining as N4-acetylated metabolite. Geriatric Pharmacokinetics: The pharmacokinetics of sulfamethoxazole 800 mg and trimethoprim 160 mg were studied in 6 geriatric subjects mean age: 78. Thus, sulfamethoxazole and trimethoprim blocks two consecutive steps in the biosynthesis of nucleic acids and proteins essential to many bacteria.
In vitro studies have shown that bacterial resistance develops more slowly with both sulfamethoxazole and trimethoprim in combination than with either sulfamethoxazole or trimethoprim alone.
Escherichia coli including susceptible enterotoxigenic strains implicated in traveler's diarrhea Klebsiella species Enterobacter species Haemophilus influenzae Morganella morganii Proteus mirabilis Proteus vulgaris Shigella flexneri Shigella sonneiQuantitative methods are used to determine antimicrobial minimum inhibitory concentrations MICs.
The MICs should be determined using a standardized procedure. The MIC values should be interpreted according to the following criteria:A report of "Susceptible" indicates that the pathogen is likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable.
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If other infections such as thrush occur while you are taking BACTRIM, tell your doctor. Side Effects Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking BACTRIM. BACTRIM helps most people with susceptible infections but it may have unwanted side effects in a few people. All medicines can have side effects.
Very rarely, people have died from complications due to certain severe skin, liver or blood reactions.
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Some Bactrim side effects can be severe. If you experience any of the following, seek medical assistance immediately: difficulty breathing or feeling out of breath, lightheadedness, trouble concentrating, slurred speech, fever, fever with chills or sore throat, worsening cough, swelling in the face or lips, swelling in the tongue or throat, severe muscle weakness, hives, swollen gums or mouth sores, burning sensation in your eyes, skin pain or sores, jaundice, a red or purple rash that blisters and peels, upper stomach pain and vomiting, dark urine, clay colored stool, watery or bloody diarrhea.
Common side effects include: mild nausea and vomiting, mild rash with itching, diarrhea. These Bactrim side effects do not require medical attention unless they persist or worsen. Never take an extra dose or additional medication to make up for a missed dose, so if it is almost time for your next dose you must skip the missed dose.
Otherwise, you can take your medication as soon as you remember it. If being administered to the elderly, side effects may be more common or worse if they are also taking diuretics, digoxin, or certain other medications while on Bactrim.
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This medicine is available only with a doctor's prescription. Generic Brands are less expensive brands that have been proven to have the same effect. Please select the desired brand. Some trimethoprim metabolites are active, however sulfamethoxazole metabolites are inactive. Given as equally divided doses every six hours for 14 days.
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Acute Exacerbations of Chronic Bronchitis in Adults: For the treatment of acute exacerbations of chronic bronchitis due to susceptible strains of Streptococcus pneumoniae or Haemophilus influenzae when in the judgment of the physician BACTRIM offers some advantage over the use of a single antimicrobial agent.
Potential Risk In The Treatment Of Pneumocystis Jirovecii Pneumonia In Patients With Acquired Immunodeficiency Syndrome AIDS AIDS patients may not tolerate or respond to BACTRIM in the same manner as non-AIDS patients.
BACTRIM belongs to a group of medicines called antibiotics.
Drug Interactions: In elderly patients concurrently receiving certain diuretics, primarily thiazides, an increased incidence of thrombocytopenia with purpura has been reported. It has been reported that BACTRIM may prolong the prothrombin time in patients who are receiving the anticoagulant warfarin.
BACTRIM may inhibit the hepatic metabolism of phenytoin.
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