Avodart

Generic Name: Avodart

What is Avodart?

It should be noted that in the case of enzyme inhibition, the long half-life may be further prolonged and it can take more than 6 months of concurrent therapy before a new steady state is reached. Administration of 12g colestyramine one hour after a 5mg single dose of dutasteride did not affect the pharmacokinetics of dutasteride. Effects of dutasteride on the pharmacokinetics of other drugsDutasteride has no effect on the pharmacokinetics of warfarin or digoxin.

In vitro interaction studies indicate that dutasteride does not inhibit the enzymes CYP1A2, CYP2A6, CYP2E1, CYP2C8, CYP2D6, CYP2C9, CYP2C19, CYP2B6 or CYP3A4. In vitro, dutasteride is not metabolized by human cytochrome P450 isoenzymes CYP1A2, CYP2A6, CYP2E1, CYP2C8, CYP2C9, CYP2C19, CYP2B6 and CYP2D6. There was also no indication of a pharmacodynamic interaction in this study. Pregnancy As with other 5 alpha reductase inhibitors, dutasteride inhibits the conversion of testosterone to dihydrotestosterone and may, if administered to a woman carrying a male foetus, inhibit the development of the external genitalia of the foetus see section 4.

Small amounts of dutasteride have been recovered from the semen in subjects receiving Avodart 0. It is not known whether a male foetus may be adversely affected if his mother is exposed to the semen of a patient being treated with dutasteride the risk of which is greatest during the first 16 weeks of pregnancy. As with all 5 alpha reductase inhibitors, when the patient's partner is or may potentially be pregnant it is recommended that the patient avoids exposure of his partner to semen by use of a condom.

For information on preclinical data, see section 5.

Effects of other drugs on the pharmacokinetics of dutasterideDutasteride is mainly eliminated via metabolism. In vitro studies indicate that this metabolism is catalysed by CYP3A4 and CYP3A5. No formal interaction studies have been performed with potent CYP3A4 inhibitors. However, in a population pharmacokinetic study, dutasteride serum concentrations were on average 1. Long-term combination of dutasteride with drugs that are potent inhibitors of the enzyme CYP3A4 e.

Further inhibition of 5-alpha reductase at increased dutasteride exposure, is not likely. However, a reduction of the dutasteride dosing frequency can be considered if side effects are noted. It should be noted that in the case of enzyme inhibition, the long half-life may be further prolonged and it can take more than 6 months of concurrent therapy before a new steady state is reached.

Administration of 12g colestyramine one hour after a 5mg single dose of dutasteride did not affect the pharmacokinetics of dutasteride. Effects of dutasteride on the pharmacokinetics of other drugsDutasteride has no effect on the pharmacokinetics of warfarin or digoxin. In vitro interaction studies indicate that dutasteride does not inhibit the enzymes CYP1A2, CYP2A6, CYP2E1, CYP2C8, CYP2D6, CYP2C9, CYP2C19, CYP2B6 or CYP3A4.

In vitro, dutasteride is not metabolized by human cytochrome P450 isoenzymes CYP1A2, CYP2A6, CYP2E1, CYP2C8, CYP2C9, CYP2C19, CYP2B6 and CYP2D6. There was also no indication of a pharmacodynamic interaction in this study.

Pregnancy As with other 5 alpha reductase inhibitors, dutasteride inhibits the conversion of testosterone to dihydrotestosterone and may, if administered to a woman carrying a male foetus, inhibit the development of the external genitalia of the foetus see section 4.

Small amounts of dutasteride have been recovered from the semen in subjects receiving Avodart 0.

How should I take Avodart?

Only take one capsule a day. Avodart is not any more effective if you exceed the recommended dose. They can include: Difficulty in getting or maintaining an erection. Decreased production of seminal fluid this does not effect sexual function. The levels and effects of Avodart are increased with: Verampiril and diltaizem used for high blood pressure Itrazonazole and ketonazole antifungal medication preparations Alpha blockers for enlarged prostate or high blood pressure If your medication changes or you would like to take some over the counter remedies please check with us or a health professional first.

Avodart is not affected by alcohol.

What should I avoid while taking Avodart?

If you are going to have eye surgery for cataracts, please tell your surgeon that you are taking or have taken an alpha blocker. In clinical studies with AVODART, the patients taking AVODART and an alpha-blocker for example tamsulosin had heart failure more often than patients taking only AVODART or only an alpha-blocker. Heart failure means your heart does not pump blood as well as it should. If you are taking AVODART and an alpha-blocker, talk to your doctor about this and other possible side effects.

In a clinical study of men at increased risk of developing prostate cancer, a serious form of prostate cancer was reported more often in men taking AVODART than in men who did not take AVODART. The reasons for this is currently unknown but may be due to the design of the clinical study. A blood test to measure the amount of a substance called PSA prostate specific antigen in your blood can help your doctor to tell if you have prostate disease, including prostate cancer.

Avodart side effects

What should you inform your doctor before using Avodart. Before taking Avodart, you should inform your doctor about having a medical history of allergy to Avodart or other medicines such as finasteride Propecia, Proscar which are very similar to Avodart. What are the ingredients used in Avodart capsules. Yes, add me to your mailing list. VideosInterviewsInfographicsComics Avodart dutasteride View Larger Image Avodart Manufactured by: GlaxoSmithKline.

What is Avodart used for. What is the dosage form and potency strength of Avodart.

Common Avodart ide effects may include:

  • Avodart helps to relieve symptoms, decrease the risk of a complete blockage of urine flow, and reduce the need for BPH surgery.

  • Most commonly, these are "preferred" on formulary brand drugs.

  • National Institutes of Health U.

  • Immediately telephone your doctor or Poisons Information Centre telephone 131126 for advice, if you think you or anyone else may have taken too much AVODART, even if there are no signs of discomfort or poisoning.

What Size Is Yours. Research suggests using Avodart may help reduce the risk of prostate cancer, but it is not known if the drug affects mortality from the cancer, reports the National Cancer Institute. Studies show a small percentage of men taking dutasteride experience erectile dysfunction and decreased or lost libido.

Rare side effects include dizziness, heart failure, and swelling in the testicles.

Where can I get more information?

  • Towers concert of year 2007 alone, overdose deaths in 2006.

  • Your name E-mail The content of this field is kept private and will not be shown publicly.