Generic Name: Order aricept
What is Order Aricept?
Time-course of the Change from Baseline in ADAS-cog Score for Patients Completing the 15- week Study. Following 3 weeks of placebo washout, scores on the ADAS-cog for both the ARICEPT treatment groups increased, indicating that discontinuation of ARICEPT resulted in a loss of its treatment effect. The duration of this placebo washout period was not sufficient to characterize the rate of loss of the treatment effect, but the 30-week study see above demonstrated that treatment effects associated with the use of ARICEPT abate within 6 weeks of treatment discontinuation.
Figure 5 illustrates the cumulative percentages of patients from each of the three treatment groups who attained the measure of improvement in ADAS-cog score shown on the X axis.
The same three change scores 7-point and 4-point reductions from baseline or no change in score as selected for the 30-week study have been used for this illustration.
The percentages of patients achieving those results are shown in the inset table. As observed in the 30-week study, the curves demonstrate that patients assigned to either placebo or to ARICEPT have a wide range of responses, but that the ARICEPT treated patients are more likely to show greater improvements in cognitive performance.
Cumulative Percentage of Patients with Specified Changes from Baseline ADAS-cog Scores. Figure 6 is a histogram of the frequency distribution of CIBIC-plus scores attained by patients assigned to each of the three treatment groups who completed 12 weeks of treatment. The differences in mean scores for ARICEPT treated patients compared to the patients on placebo at Week 12 were 0.
Patients with VaD typically experience a stepwise decline in function, in contrast to patients with AD, who often experience a gradual, progressive decline. Like all forms of dementia, VaD results in significant physical, financial and emotional burden for patients and their families.
Study details The study included patients with VaD and excluded those with a diagnosis of AD. Patients were selected using research criteria specifically designed to identify patients with VaD. The criteria were developed by the National Institute of Neurological Disorders and Stroke NINDS with support from the Associate Internationale pour la Recherche et l'Enseignment en Neurosciences AIREN. The NINDS-AIREN criteria define VaD as cognitive decline involving memory loss, as well as impairment in at least two other cognitive domains that interfere with activities of daily life.
The majority of participants had a history of stroke. Other adverse events that occurred significantly more often in ARICEPT R -treated patients were accidental injury, insomnia, leg cramps, rhinitis, and abnormal dreams. Overall, 491 patients 79. In a progressively degenerative disease such as Alzheimer's, improvement, stabilization or a less-than-expected decline over time is considered a positive response to treatment. Individual responses to treatment may vary.
Some people may experience nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue or loss of appetite. Gli anticolinergici terziari, come l'atropina, possono essere utilizzati quali antidoto in caso di sovradosaggio di ARICEPT.
How should I take Order Aricept?
Some clastogenic effects were observed in vitro at concentrations overtly toxic to the cells and more than 3000 times the steady-state plasma concentrations. No clastogenic or other genotoxic effects were observed in the mouse micronucleus model in vivo. There was no evidence of oncogenic potential in long term carcinogenicity studies in either rats or mice.
Donepezil hydrochloride had no effect on fertility in rats, and was not teratogenic in rats or rabbits, but had a slight effect on still births and early pup survival when administered to pregnant rats at 50 times the human dose see section 4. Excipients with known effect: 87.
What should I avoid while taking Order Aricept?
Two hundred and forty eight 248 patients with severe Alzheimer's disease were randomized to ARICEPT or placebo. Probable AD was diagnosed in the majority of the patients 83. Study Outcome Measures: The effectiveness of treatment with ARICEPT was determined using a dual outcome assessment strategy that evaluated cognitive function using an instrument designed for more impaired patients and overall function through caregiver-rated assessment.
Daily function was assessed using the Modified Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory for Severe Alzheimer's Disease ADCS-ADL-severe.
The ADCS-ADL-severe is derived from the Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory, which is a comprehensive battery of ADL questions used to measure the functional capabilities of patients.
Order Aricept side effects
In this study, there were no important differences in the type of adverse events in patients taking ARICEPT with or without memantine.
Voluntary reports of adverse events temporally associated with ARICEPT that have been received since market introduction that are not listed above, and for which there are inadequate data to determine the causal relationship with the drug include the following: abdominal pain, agitation, cholecystitis, confusion, convulsions, hallucinations, heart block all typeshemolytic anemia, hepatitis, hyponatremia, neuroleptic malignant syndrome, pancreatitis, and rash.
Formal pharmacokinetic studies evaluated the potential of ARICEPT for interaction with theophylline, cimetidine, warfarin, digoxin and ketoconazole. A small effect of CYP2D6 inhibitors was identified in a population pharmacokinetic analysis of plasma donepezil concentrations measured in patients with Alzheimer's disease. This result is consistent with the conclusion that CYP2D6 is a minor metabolic pathway of donepezil.
A synergistic effect may be expected when cholinesterase inhibitors are given concurrently with succinylcholine, similar neuromuscular blocking agents or cholinergic agonists such as bethanechol. Age: No formal pharmacokinetic study was conducted to examine age-related differences in the pharmacokinetics of ARICEPT.
Common Order Aricept ide effects may include:
Give ARICEPT exactly as prescribed by the doctor.
These side effects include:Lung problems like asthma can aggravate with the use of Aricept in some.
With WebMD's Medicine Cabinet, you can check interactions with drugs.
If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist for further advice.
This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Low-dose aspirin, as prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention usually at dosages of 81-325 milligrams per dayshould be continued. Consult your doctor or pharmacist for more details. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911.
Where can I get more information?
Overdosage with cholinesterase inhibitors can result in cholinergic crisis characterized by severe nausea, vomiting, salivation, sweating, bradycardia, hypotension, respiratory depression, collapse, and convulsions.
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