Generic Name: Arcoxia
What is Arcoxia?
The clinical significance of these increases is unknown, and higher doses of PREMARIN were not studied in combination with etoricoxib. These increases in estrogenic concentration should be taken into consideration when selecting post-menopausal hormone therapy for use with etoricoxib because the increase in oestrogen exposure might increase the risk of adverse events associated with HRT.
Digoxin: Etoricoxib 120 mg administered once daily for 10 days to healthy volunteers did not alter the steady-state plasma AUC0-24hr or renal elimination of digoxin. This increase is not generally important for most patients. However, patients at high risk of digoxin toxicity should be monitored for this when etoricoxib and digoxin are administered concomitantly. Effect of etoricoxib on drugs metabolised by sulfotransferasesEtoricoxib is an inhibitor of human sulfotransferase activity, particularly SULT1E1, and has been shown to increase the serum concentrations of ethinyl estradiol.
While knowledge about effects of multiple sulfotransferases is presently limited and the clinical consequences for many drugs are still being examined, it may be prudent to exercise care when administering etoricoxib concurrently with other drugs primarily metabolised by human sulfotransferases e.
Effect of etoricoxib on drugs metabolised by CYP isoenzymesBased on in vitro studies, etoricoxib is not expected to inhibit cytochromes P450 CYP 1A2, 2C9, 2C19, 2D6, 2E1 or 3A4.
Etoricoxib may slightly increase your risk of heart attack and stroke and this is why it should not be used in those who have already had heart problems or stroke. Warnings and precautions Talk to your doctor or pharmacist before taking ARCOXIA if: You have a history of stomach bleeding or ulcers.
Children and adolescents Do not give this medicine to children and adolescents under 16 years of age. Other medicines and ARCOXIA Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription. In particular if you are taking any of the following medicines, your doctor may want to monitor you to check that your medicines are working properly, once you start taking ARCOXIA: medicines that thin your blood anticoagulantssuch as warfarin rifampicin an antibiotic methotrexate a drug used for suppressing the immune system, and often used in rheumatoid arthritis ciclosporin or tacrolimus drugs used for suppressing the immune system lithium a medicine used to treat some types of depression medicines used to help control high blood pressure and heart failure called ACE inhibitors and angiotensin receptor blockers, examples include enalapril and ramipril, and losartan and valsartan diuretics water tablets digoxin a medicine our risk of side effects aspirin, the risk of stomach ulcers is greater if you take ARCOXIA with aspirin.
If you are currently taking low-dose aspirin to prevent heart attacks or stroke, you should not stop taking aspirin until you talk to your doctoraspirin and other non-steroidal anti-inflammatory drugs NSAIDs : do not take high dose aspirin or other anti-inflammatory medicines while taking ARCOXIA. ARCOXIA with food and drink The onset of the effect of ARCOXIA may be faster when taken without food.
ARCOXIA contains lactose If you have been told by your doctor that you are unable to tolerate some sugars, contact your doctor before taking this medicinal product. How to take ARCOXIA Always take this medicine exactly as your doctor has told you.
The recommended dose is: Osteoarthritis The recommended dose is 30 mg once a day, increase to a maximum of 60 mg once a day if needed. Rheumatoid arthritis The recommended dose is 60 mg once a day, increased to a maximum of 90 mg once a day if needed. Ankylosing spondylitis The recommended dose is 60 mg once a day, increased to a maximum of 90 mg once a day if needed. Acute pain conditions Etoricoxib should be used only for the acute painful period. Gout The recommended dose is 120 mg once a day which should only be used for the acute painful period, limited to a maximum of 8 days treatment.
Postoperative dental surgery pain The recommended dose is 90 mg once daily, limited to a maximum of 3 days treatment.
How should I take Arcoxia?
Gout The recommended dose is 120 mg once a day which should only be used for the acute painful period, limited to a maximum of 8 days treatment. Postoperative dental surgery pain The recommended dose is 90 mg once daily, limited to a maximum of 3 days treatment. People with liver problems If you have mild liver disease, you should not take more than 60 mg a day.
If you have moderate liver disease, you should not take more than 30 mg a day. Use in children and adolescents ARCOXIA tablets should not be taken by children or adolescents under 16 years of age. Elderly No dose adjustment is necessary for elderly patients.
What should I avoid while taking Arcoxia?
Dosing with food a high-fat meal had no effect on the extent of absorption of etoricoxib after administration of a 120-mg dose. These data are not considered clinically significant.
Elimination of etoricoxib occurs almost exclusively through metabolism followed by renal excretion. Steady state concentrations of etoricoxib are reached within seven days of once daily administration of 120 mg, with an accumulation ratio of approximately 2, corresponding to a half-life of approximately 22 hours.
Characteristics in patientsElderly patients: Pharmacokinetics in the elderly 65 years of age and older are similar to those in the young. Gender: The pharmacokinetics of etoricoxib are similar between men and women.
Arcoxia side effects
Arcoxia has not been adequately studied in children. Therefore, Arcoxia should not be given to children. Arcoxia works equally well in older and younger adult patients. Adverse experiences may occur at a higher incidence in older patients compared to younger patients. If you are elderly ie over 65 years of ageyour doctor will want to appropriately keep a check on you.
No dosage adjustment is necessary for older patients. Tell your doctor if you are taking any other medicines, including medicines that you buy without a prescription from your pharmacy, supermarket or health food shop.
These medicines may be affected by Arcoxia or may affect how well it works.
Common Arcoxia ide effects may include:
Before the infection I had a pain inhibitor, arcoxia, ibuprofen is 10 x more effective for the pain.
No dose adjustment is necessary for elderly patients.
Although less common, some side effects may include skin rashes or itching, muscle pains or cramps, chest pain, or coughing.
Merck has since produced results from further studies of Arcoxia, but doctors questioned those results because Merck compared Arcoxia in its tests to another, older anti-inflammatory drug, diclofenac - widely used elsewhere, but not in the U.
Across clinical pharmacology studies, ARCOXIA produced dose-dependent inhibition of COX-2 without inhibition of COX-1 at doses up to 150 mg daily.
Etoricoxib did not inhibit gastric prostaglandin synthesis and had no effect on platelet function. Cyclooxygenase is responsible for generation of prostaglandins. Two isoforms, COX-1 and COX-2, have been identified.
Where can I get more information?
The incidence of confirmed congestive heart failure adverse events events that were serious and resulted in hospitalisation or a visit to an emergency department was non-significantly higher with etoricoxib than diclofenac 150 mg, and this effect was dose-dependent.
Pregnancy and Arcoxia Taking Arcoxia when you are pregnant, trying for a baby, or breast-feeding may not be suitable as there are a range of side effects of this drug that may cause a reaction.