Generic Name: Generic arava
What is Generic Arava?
Talk to your doctor if you become pregnant within two years after stopping treatment with leflunomide. The risk is highest in patients with liver disease or those taking other drugs known to cause liver damage. So, if you drink or have ever drunk large amounts of alcohol or if you have or have ever had liver disease, you may not be a candidate for treatment with leflunomide.
Results from these studies showed that leflunomide reduced the symptoms of RA and slowed the process of damage to joints and related structures. This study was followed by a 1-year double-blind extension MN304. This study was followed by a 6-month blinded extension MN303. Patients who completed both of these studies were given the opportunity to participate in a 1-year double-blind extension, in which all patients received an active treatment those who had originally received leflunomide continued on that drug and placebo patients received sulfasalazine.
Leflunomide was also similar to sulfasalazine in RA disease control.
Patients who completed both of these studies were given the opportunity to participate in a 1-year double-blind extension, in which all patients received an active treatment those who had originally received leflunomide continued on that drug and placebo patients received sulfasalazine.
Leflunomide was also similar to sulfasalazine in RA disease control. A systematic review of results from studies of conventional DMARDs the review encompassed 25 trials including almost 4,000 patients has shown that leflunomide and other DMARDs are significantly more effective than placebo and similar in their effectiveness in slowing joint erosion. Results from the extensions of the pivotal studies of leflunomide have shown that benefits in terms of slowing of progression as shown by x-ray evidence continue beyond 2 years.
Similar to other DMARD treatments, leflunomide is effective in improving function as well as reducing disease activity. Functional improvements as measured by the Health Assessment Questionnaire HAQ are similar in scope to decreases in disease activity. A study looking at short-term changes in functioning in 807 RA patients who received leflunomide found that over a 6-month period HAQ scores fell indicating improvement by 0.
These include rash, hives, difficulty breathing, chest pain, new or worsening cough, skin peeling or blistering, and pale skin. If you experience any of these, or nausea, extreme tiredness, unusual bleeding or bruising, lack of energy, loss, appetite loss, pain affecting the upper right part of the stomach, yellowing of the skin or eyes, dark-colored urine, or flu-like symptoms, contact your doctor immediately.
You should have your blood pressure checked before starting leflunomide and regularly during treatment. Alert your doctor immediately if you develop any infection while taking leflunomide.
Also, let your doctor know if you have ever had a serious infection, if you frequently get infections, or if you have ever had a condition that affects your immune system function eg. Make sure to tell your doctor if you have ever had TB.
Your doctor will give you a test to determine whether you have TB. If you are taking leflunomide, talk to your doctor before taking Tylenol acetaminophen or non-steroidal anti-inflammatory drugs NSAIDssuch as aspirin, Advil or Motrin ibuprofenor Aleve or Naprosyn naproxen or cholesterol-lowering medications statinsEnbrel etanerceptthe DMARD hydroxychloroquine, iron products, isoniazid a TB treatment contained in Nydrazid and Rifamatemethotrexate, niacin nicotinic acidor rifampin Rifadin, Rimactane, Rifamate, Rifater.
How should I take Generic Arava?
CYP450 inhibitors and inducersIn vitro inhibition studies in human liver microsomes suggest that cytochrome P450 CYP 1A2, 2C19 and 3A4 are involved in leflunomide metabolism. An in vivo interaction study with leflunomide and cimetidine non-specific weak cytochrome P450 CYP inhibitor has demonstrated a lack of a significant impact on A771726 exposure.
The mechanism of this effect is unclear. A pharmacokinetic interaction with oral contraceptives was observed with A771726 see below. The following pharmacokinetic and pharmacodynamic interaction studies were conducted with A771726 principal active metabolite of leflunomide.
As similar drug-drug interactions cannot be excluded for leflunomide at recommended doses, the following study results and recommendations should be considered in patients treated with leflunomide: Effect on repaglinide CYP2C8 substrate There was an increase in mean repaglinide Cmax and AUC 1. Patients should be closely monitored for signs and symptoms of excessive exposure to the medicinal products and reduction of the dose of these medicinal products should be considered.
What should I avoid while taking Generic Arava?
If the liver enzyme elevation is likely leflunomide-induced, perform the accelerated drug elimination procedure and monitor liver function tests LFTs weekly until normalized. If leflunomide-induced liver injury is unlikely because some other cause has been found, resumption of therapy may be considered.
Instruct patients to immediately contact their health care professional if signs and symptoms of liver disease develop e. When methotrexate is given concomitantly, follow the American College of Rheumatology ACR guidelines for monitoring methotrexate liver toxicity i.
Counsel patients about the reproductive risk and contraception requirements during leflunomide treatment. Do not initiate therapy in females of reproductive potential until pregnancy testing is performed with confirmed negative results. Females of reproductive potential should use effective contraception during treatment and during the accelerated drug elimination procedure after leflunomide treatment is complete. If a woman becomes pregnant while taking leflunomide, she should stop the medication, be apprised of the potential fetal risks, and undergo an accelerated drug elimination procedure to achieve non-detectable plasma concentrations of teriflunomide, the active metabolite of leflunomide.
Generic Arava side effects
In placebo-controlled studies with the active metabolite, teriflunomide, elevations in blood pressure were observed in some subjects. Hypertension occurred in some individuals. Blood pressure should be monitored prior to leflunomide initiation and periodically during treatment. Elevated blood pressure during treatment should be appropriately managed according to current clinical guidelines.
Leflunomide is contraindicated for use during pregnancy due to the potential for fetal harm and. Exclude the possibility of pregnancy prior to treatment.
Common Generic Arava ide effects may include:
Combinations with other treatmentsThe use of leflunomide with antimalarials used in rheumatic diseases e.
Predictions about the interaction can be made based on the metabolic pathways of both drugs.
It may take several weeks after starting leflunomide to experience an improvement in joint pain or swelling.
Instruct patients to immediately contact their health care professional if signs and symptoms of liver disease develop e.
Pustular psoriasis and worsening of psoriasis have been reported after the use of leflunomide. Treatment withdrawal may be considered taking into account patient's disease and past history. InfectionsIt is known that medicinal products with immunosuppressive properties - like leflunomide - may cause patients to be more susceptible to infections, including opportunistic infections.
Infections may be more severe in nature and may, therefore, require early and vigorous treatment. In the event that severe, uncontrolled infections occur, it may be necessary to interrupt leflunomide treatment and administer a washout procedure as described below.
Where can I get more information?
It works by hindering the growth of hyper active inflammatory cells.
Talk to your doctor if you become pregnant within two years after stopping treatment with leflunomide.