Generic Name: Arava
What is Arava?
As leflunomide can enter breast milk it should not be taken during breastfeeding. If a patient receiving leflunomide becomes pregnant the drug should be stopped and washed out immediately.
There is no special reason to restrict leflunomide use to the treatment of rheumatoid arthritis. It can be beneficial in treating other auto-immune conditions. There is good evidence that leflunomide can help people with psoriatic arthritis, and it is approved for treating this condition.
There is less evidence about its value in other disorders. It may be helpful in systemic lupus erythematosus. However, it is only licensed for patients with rheumatoid arthritis and psoriatic arthritis. There is substantial evidence that leflunomide is an effective and relatively safe drug for use in patients with rheumatoid arthritis. Common side effects of leflunomide, including diarrhoea, high blood pressure, weight loss and raised liver function tests, do not usually result in major clinical problems.
The 11 days do not need to be consecutive unless there is a need to lower the plasma level rapidly. Verify plasma levels less than 0. If plasma levels are higher than 0. Additional safety information ARAVA is contraindicated in patients with known hypersensitivity to leflunomide, teriflunomide, or any of the other components of ARAVA.
Severe infections including sepsis, which may be fatal, have been reported. This site is intended for use by U. ARAVA is a pyrimidine synthesis inhibitor indicated for the treatment of adults with active rheumatoid arthritis. LLC at 1-800-633-1610 or FDA at 1-800-FDA-1088 or www. Teratogenicity and embryo-lethality occurred in animals administered leflunomide at doses lower than the human exposure level.
Exclude pregnancy before the start of treatment with ARAVA in females of reproductive potential.
How should I take Arava?
After 12 months with active treatment, the ACR response rates in leflunomide patients were 52. In study MN302 leflunomide was significantly less effective than methotrexate.
However, in study US301 no significant differences were observed between leflunomide and methotrexate in the primary efficacy parameters. No difference was observed between leflunomide and sulphasalazine study MN301. The leflunomide treatment effect was evident by 1 month, stabilised by 3 to 6 months and continued throughout the course of treatment. A randomised, double-blind, parallel-group non-inferiority study compared the relative efficacy of two different daily maintenance doses of leflunomide, 10 mg and 20 mg.
What should I avoid while taking Arava?
What Arava is and what it is used for Arava belongs to a group of medicines called anti-rheumatic medicines. What you need to know before you take Arava Do not take Arava if you have ever had an allergic reaction to leflunomide especially a serious skin reaction, often accompanied by fever, joint pain, red skin stains, or blisters e. Stevens-Johnson syndrome or to any of the other ingredients of this medicine listed in section 6or if you are allergic to teriflunomide used to treat multiple sclerosisif you have any liver problems, if you have moderate to severe kidney problems, if you have severely low numbers of proteins in your blood hypoproteinaemiaif you suffer from any problem which affects your immune system e.
AIDSif you have any problem with your bone marrow, or if you have low numbers of red or white cells in your blood or a reduced number of blood platelets, if you are suffering from a serious infection, if you are pregnant, think you may be pregnant, or are breast-feeding.
Warnings and precautions Talk to your doctor, pharmacist or nurse before taking Arava if you have ever suffered from interstitial lung disease if you have ever had tuberculosis or if you have been in close contact with someone who has or has had tuberculosis.
Arava side effects
Who else should not take Arava. Arava should not be used by nursing mothers. Arava is not recommended for patients with serious immune deficiencies or severe uncontrolled infections. If you have other diseases such as kidney problems, tell your doctor.
How might Arava affect my liver. Does Arava cause any side effects. What if I am taking other medications. Having a cancer diagnosis can have a significant financial impact for patients, so having a benefit like this is very welcome.
Common Arava ide effects may include:
Patients who receive a reduction in dosage will be monitored carefully to check for plasma concentrations.
In such cases patients should refrain from driving cars and using machines.
If evidence of bone marrow suppression occurs in a patient taking leflunomide, stop treatment with leflunomide, and perform an accelerated drug elimination procedure to reduce the plasma concentration of the leflunomide active metabolite, teriflunomide.
Data are not available to determine if leflunomide is present in human milk, the effects of leflunomide on the breast-fed infant, or the effects of lefunomide on milk production.
In people with arthritis, this medicine can help reduce pain and swelling inflammation in the joints, improve day to day function, and prevent long-term damage caused by joint inflammation.
The suppression of the immune system can also make it a bit harder for the body to fight infections, so people taking Arava should report any fevers or infections to their doctor. Monthly blood tests are important to ensure that Arava does not harm the liver or blood counts.
Patients should stop drinking alcohol to reduce the chances of liver side effects. Arava may cause birth defects and result in miscarriage.
Where can I get more information?
Possible side effects 5.
There is no dose adjustment recommended in patients with mild renal insufficiency.