Generic Name: Anafranil

What is Anafranil?

Call the healthcare provider between visits as needed, especially if you have concerns about symptoms. Call a healthcare provider right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying attempts to commit suicide new or worse depression new or worse anxiety feeling very agitated or restless panic attacks trouble sleeping insomnia new or worse irritability acting aggressive, being angry, or violent acting on dangerous impulses an extreme increase in activity and talking mania other unusual changes in behavior or mood Visual problems eye pain changes in vision swelling or redness in or around the eye Only some people are at risk for these problems.

Who should not take Anafranil. Stopping an antidepressant medicine suddenly can cause other symptoms. Antidepressants are medicines used to treat depression and other illnesses. It is important to discuss all the risks of treating depression and also the risks of not treating it. Patients and their families or other caregivers should discuss all treatment choices with the healthcare provider, not just the use of antidepressants.

Antidepressant medicines have other side effects.

For depression, obsessive-compulsive disorders and phobias, treatment is usually started with a low dose of 2 or 3 tablets 50 to 75 mg each day. The dose can be raised slowly up to 4 to 6 tablets each day. Some people will need higher doses than others because each person's body chemistry is different. Once you are feeling better, your doctor may be able to slowly reduce the dose, usually down to 2 to 4 tablets each day.

For muscle weakness accompanying narcolepsy, the dose is usually from 1 to 3 tablets 25 to 75 mg each day. If you are older than 65 years, your doctor will probably start with a low dose e.

The dose is gradually increased over about ten days to 2 to 3 tablets each day and kept at that dose for the rest of your treatment.

Take the tablets in 2 or 3 doses spread over the day unless your doctor advises you otherwise. If you have narcolepsy and you have trouble sleeping at night, take the last dose before evening to avoid making your insomnia worse. The length of treatment will depend on your condition and on how well the medicine works. For depression, the length of treatment will depend on how quickly your symptoms improve.

This type of medicine takes time to work, so don't be discouraged if you don't feel better right away. Otherwise, take the dose as soon as you remember, and then go back to taking the tablets as you would normally.

Do not take a double dose to make up for the one that you missed. This may increase the chance of you getting an unwanted side effect.

How should I take Anafranil?

Mention any serious reactions you may have had to other similar medications. If you are taking other prescription drugs or supplements, you should check with your doctor or pharmacist before taking Anafranil. This drug may interact with other medications or supplements, including MAOIs, antihistamines, other antidepressants, antacids, antifungal creams and medications, sleeping pills, antipsychotics, vitamins, minerals, high blood pressure medications, herbal products, and more.

Anafranil, along with other TCAs, carries significant warnings of which to be aware. Your doctor will help you decide if the benefits of this medication outweigh the risks of using it. Serious side effects of this drug may include:Do not stop taking Anafranil abruptly as your body may have become accustomed to the medication. Slowly tapering off of this medication will help reduce the occurrence and severity of withdrawal symptoms.

What should I avoid while taking Anafranil?

After you have stopped taking Anafranil, you should still be careful for 1 or 2 weeks since some of the effects of the medicine will still be in your body. Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Anafranil. All medicines can have side effects.

Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects. If you are over 65 years old, you should be especially careful while taking this medicine.

Anafranil side effects

Do not stop taking this medication without consulting your doctor. Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

The dose depends on individual circumstances, but is usually started low and increased gradually as required and as prescribed by the doctor. When discontinuing the medication, the dosage should be reduced gradually to prevent withdrawal effects. Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications.

Common Anafranil ide effects may include:

  • Caution is indicated in treating patients with known liver disease, and periodic monitoring of hepatic function is recommended in such patients.

  • Prescriptions for clomipramine hydrochloride should be written for the smallest quantity of capsules consistent with good patient management, in order to reduce the risk of overdose.

  • Do not share this medicine with others for whom it was not prescribed.

  • Make sure your doctor or pharmacist knows if you are taking any of the following:Always tell your doctor or pharmacist about all the medicines you are taking.

Caution is indicated in treating patients with known liver disease, and periodic monitoring of hepatic enzyme levels is recommended in such patients. Although no instances of severe hematologic toxicity were seen in the premarketing experience with Anafranil, there have been postmarketing reports of leukopenia, agranulocytosis, thrombocytopenia, anemia, and pancytopenia in association with Anafranil use. As is the case with tricyclic antidepressants to which Anafranil is closely related, leukocyte and differential blood counts should be obtained in patients who develop fever and sore throat during treatment with Anafranil.

More than 30 cases of hyperthermia have been recorded by nondomestic postmarketing surveillance systems.

Where can I get more information?

  • Drugs containing pain relievers can increase risk for bleeding when taken with Anafranil.

  • Most cases occurred when clomipramine was used in combination with other drugs.