Generic Name: Anafranil
What is Anafranil?
Monoamine Oxidase Inhibitors MAOIs The use of MAOIs intended to treat psychiatric disorders with Anafranil or within 14 days of stopping treatment with Anafranil is contraindicated because of an increased risk of serotonin syndrome.
Myocardial Infarction Anafranil is contraindicated during the acute recovery period after a myocardial infarction. Distribution CMI distributes into cerebrospinal fluid CSF and brain and into breast milk. Metabolism CMI is extensively biotransformed to DMI and other metabolites and their glucuronide conjugates. Elimination Evidence that the C and AUC for CMI and DMI may increase disproportionately with increasing oral doses suggests that the metabolism of CMI and DMI may be capacity limited.
Interactions Co-administration of haloperidol with CMI increases plasma concentrations of CMI. Animal Toxicology Phospholipidosis and testicular changes, commonly associated with tricyclic compounds, have been observed with Anafranil. Talk to your, or your family member'shealthcare provider about: all risks and benefits of treatment with antidepressant medicines all treatment choices for depression or other serious mental illness What is the most important information I should know about antidepressant medicines, depression and other serious mental illnesses, and suicidal thoughts or actions.
Call the healthcare provider between visits as needed, especially if you have concerns about symptoms. Call a healthcare provider right away if you or your family member has any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying attempts to commit suicide new or worse depression new or worse anxiety feeling very agitated or restless panic attacks trouble sleeping insomnia new or worse irritability acting aggressive, being angry, or violent acting on dangerous impulses an extreme increase in activity and talking mania other unusual changes in behavior or mood Visual problems eye pain changes in vision swelling or redness in or around the eye Only some people are at risk for these problems.
Who should not take Anafranil. Stopping an antidepressant medicine suddenly can cause other symptoms.
Anafranil FDA WarningBack to TopSuicidality and Antidepressant DrugsAntidepressants increased the risk compared to placebo of suicidal thinking and behavior suicidality in children, adolescents, and young adults in short-term studies of major depressive disorder MDD and other psychiatric disorders.
Anafranil works by raising levels of norepinephrine a neurotransmitter to normal levels. This drug is used to reduce the anxiety and unpleasant thoughts that cause obsessive-compulsive behaviors such as repeating an ordinary task many times, and help such a patient lead a more normal lifestyle.
It is also used to treat depression. Anafranil works by inhibiting norepinephrine and serotonin reuptake. Of the tricyclic antidepressants, clomipramine is the most selective and potent inhibitor of serotonin reuptake. Why is this drug prescribed. Anafranil is FDA-approved to treat obsessive-compulsive disorder in children age 10 and up and in adults. Warnings and Precautions Anafranil is not recommended for use in children under ten years old.
Adolescents should receive smaller doses than the recommended adult dose. Anafranil may cause seizures in patients with a history of seizures or other factors that make seizures more likely such as brain damage, alcoholism, and use of Anafranil with other drugs that lower the seizure threshold.
Taking smaller doses may reduce the incidence of seizures. Anafranil is not addictive. Suddenly discontinuing use of Anafranil may cause withdrawal, and dosage should be reduced gradually to minimize withdrawal symptoms.
How should I take Anafranil?
Abnormal ECG Anaphylactic and anaphylactoid reactions including hypotension Neuroleptic malignant syndrome NMS - a potentially fatal side effect of antidopaminergic agents such as antipsychotics, tricyclic antidepressants and antiemetics drugs that relieve nausea and vomiting. NMS develops over a period of days or weeks and is characterised by the following symptoms: Tremor Muscle rigidity Mental status change such as confusion, delirium, mania, hypomania, agitation, coma, etc.
Maudsley Prescribing Guidelines in Psychiatry 11th ed. Go to top of the page4. As a precaution against possible QTc prolongation and serotonergic toxicity, adherence to the recommended doses of Anafranil is advised and any increase in dose should be made with caution if other serotonergic agents are co-administered see sections 4.
The dosage should be adapted to the individual patient's condition. The aim is to achieve an optimum effect while keeping the doses as low as possible and increasing them cautiously.
What should I avoid while taking Anafranil?
Pooled analyses of short-term 4 to 16 weeks placebo-controlled trials of 9 antidepressant drugs SSRIs and others in children and adolescents with major depressive disorder MDDobsessive compulsive disorder OCDor other psychiatric disorders a total of 24 trials involving over 4400 patients have revealed a greater risk of adverse events representing suicidal thinking or behavior suicidality during the first few months of treatment in those receiving antidepressants.
No suicides occurred in these trials. Download the complete FDA warning concerning antidepressant use in children and adults. Clomipramine hydrochloride Anafranil is a tricyclic antidepressant used to treat depression and obsessive-compulsive disorder OCD. It may also be used to treat other conditions as determined by your doctor. Clomipramine is indicated for the treatment of obsessions and compulsions in patients with Obsessive-Compulsive Disorder OCD. The effectiveness of clomipramine for long-term use i.
The physician who elects to use clomipramine for extended periods should periodically re-evaluate the long term usefulness of the drug for the individual patient.
Anafranil side effects
If I knew it was an anti depressant it would have made sense. I've been on Aropax myself and know the side effects. My doc a beautiful sexy blond 30yr old warned me that a side effect is a much lower libido. I loved it, no change in my libido, only much longer staying power and delayed orgasms. There are other side effects as well and I stopped taking it because I do not like to be dependant on any medication.
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Common Anafranil ide effects may include:
I suffered with depression on and off for 40 years, and of all the antidepressants I tried which was most of them Anafranil was the only one to completely get rid of my depression and panic attacks.
Effect of ageIn elderly patients, clomipramine has relatively low clearance in comparison to younger adult patients.
Caution with drugs that lower seizure threshold.
What Mental Health Conditions Are Treated with Anafranil.
A dangerous drug interaction could occur. ContinuePRINT From Healthy Resources How Is Atrial Fibrillation Affecting You. Brand Names: Anafranil Generic Name: clomipramine Pronunciation: kloe MI pra meen What is clomipramine Anafranil.
What should I discuss with my healthcare provider before taking clomipramine Anafranil. How should I take clomipramine Anafranil.
Where can I get more information?
The side effects listed below have also been reported: Increase in appetite and weight gain Headaches dizziness nausea constipation dry mouth increased sweating shaking hands tremor difficulty in passing urine problems with their eyes, feeling tired or sleepy sexual disturbances.
N-desmethylclomipramine can be formed by several P450 enzymes, primary CYP3A4, CYP2C19, and CYP1A2.