Generic Anafranil Sr
Generic Name: Generic anafranil sr
What is Generic Anafranil Sr?
These measures are recommended for up to 12 hours or ever longer after the overdose, since the anticholinergic effect of the drug may help to reduce drug absorption. Since it has been reported that phyotigmine may cause severe bradycardia, asystole, and seizures, it's use is not recommended in cases of overdosage with Anafranil.
The formation of pharmacobezoar may cause slow but continual release and absorption of clomipramine which may lead to overdose complications, including death, hours after drug ingestion and initial treatment with gastric lavage and activated charcoal.
Since gastric lavage may be ineffective and could further increase systemic drug levels, consideration should be given to physical removal of the pharmacobezoar by endoscopy or surgery in selected patients. Since these cases are rare, there is insufficient clinical data regarding optimal treatment which should take into account the size and location of the pharmacobezoar, patient symptoms and condition and drug levels Go to top of the page5.
Metabolism:The primary route of clomipramine metabolism is demethylation to form the active metabolite, N-desmethylclomipramine. N-desmethylclomipramine can be formed by several P450 enzymes, primary CYP3A4, CYP2C19, and CYP1A2. Clomipramine and N-desmethylclomipramine are hydroxylated to form 8-hydroxyclomipramine or 8-hydroxy-N-desmethylclomipramine. Clomipramine is also hydroxylated at the 2-position and N-desmethylclomipramine can be further demethylated to form didesmethylclomipramine.
The 2- and 8-hydroxy metabolites are excreted primarily as glucuronides in the urine.
Therefore, concomitant administration of drugs that can cause accumulation of clomipramine should be avoided. Equally, concomitant administration of drugs that can prolong the QTc interval should be avoided see sections 4.
Interactions with other medicinal products and other forms of interaction. It is established that hypokalaemia is a risk-factor of QTc prolongation and Torsades de pointes. Therefore, hypokalaemia should be treated before initiating treatment with Anafranil and Anafranil should be used with caution when combined with SSRIs, SNaRIs or diuretics see section 4.
It appears that the occurrence of seizures is dose dependent, therefore the recommended total daily dose of Anafranil should not be exceeded. Caution is called for when giving tricyclic antidepressants to patients with with severe hepatic disease and tumours of the adrenal medulla e.
Concomitant treatment of Anafranil and electroconvulsive therapy should only be resorted to under careful supervision. Elderly patients are particularly liable to experience adverse effects, especially agitation, confusion, and postural hypotension. Precautions:Before initiating treatment it is advisable to check the patient's blood pressure, because individuals with hypotension or a labile circulation may react to the drug with a fall in blood pressure.
White Blood cell CountAlthough changes in the white blood cell count have been reported with Anafranil only in isolated cases, periodic blood cell counts and monitoring for symptoms such as fever and sore throat are called for, particularly during the first few months of therapy. They are also recommended during prolonged therapy.
It is advisable to monitor cardiac and hepatic function during long-term therapy with Anafranil. In patients with hepatic and renal disease, periodic monitoring of the hepatic enzyme levels and renal function is recommended.
Anticholinergic effectsBecause of its anticholinergic properties, Anafranil should be used with caution in patients with a history of increased intra-ocular pressure, narrow angle glaucoma or urinary retention e.
How should I take Generic Anafranil Sr?
Anafranil must not be used by children of all ages. If in case this particular medicine has been prescribed to your kid, you have to be extra sure and talk with your doctor if this medication is ideal for child consumption. It is always to be safe than sorry, especially when dealing with medication involving depression. Weitere Informationen zur Suche finden Sie in der Online-Hilfe. Das breite Informationsangebot von compendium.
Clomipramine, sold under the brand name Anafranil among others, is a tricyclic antidepressant TCA. It may decrease the risk of suicide in those over the age of 65. It is taken by mouth.
What should I avoid while taking Generic Anafranil Sr?
Prescriptions for Anafranil should be written for the smallest quantity of tablets and capsules consistent with good patient management, in order to reduce the risk of overdose. Other Psychiatric EffectsMany patients with panic disorders experience intensified anxiety symptoms at the start of the treatment with antidepressants. As improvement in depression may not occur for the first two to four weeks treatment, patients should be closely monitored during this period.
Cardiac and Vascular DisordersAnafranil should be administered with particular precaution in patients with cardiovascular disorders, especially those with cardiovascular insufficiency, conduction disorders, e. There may be a risk of QTc prolongation and Torsade de Pointes, particularly at supra-therapeutic doses or supra-therapeutic plasma concentrations of clomipramine, as occur in the case of co-medication with selective serotonin reuptake inhibitors SSRIs.
Equally, concomitant administration of drugs that can prolong the QTc interval should be avoided see section 4. It is established that hypokalemia is a risk-factor of QTc prolongation and Torsade de Pointes. Therefore, hypokalemia should be treated before initiating treatment with Anafranil see section 4.
Generic Anafranil Sr side effects
Characteristics in patients: In elderly patients, plasma clomipramine concentrations may be higher for a given dose than would be expected in younger patients because of reduced metabolic clearance. The effects of hepatic and renal impairment on the pharmacokinetics of clomipramine have not been determined. The clinical relevance of these findings is unknown.
Children and adolescents In children and adolescents, there is not sufficient evidence of safety and efficacy of Anafranil in the treatment of depressive states of varying aetiology and symptomatology, phobias and panic attacks, cataplexy accompanying narcolepsy and chronic painful conditions. Before initiating treatment with Anafranil, hypokalemia should be treated see 4.
Common Generic Anafranil Sr ide effects may include:
Before having surgery, tell your doctor or dentist that you are taking this medication.
A meta-analysis of placebo-controlled clinical trials of antidepressant drugs in adult patients with psychiatric disorders showed an increased risk of suicidal behaviour with antidepressants compared to placebo in patients less than 25 years old.
Some medicines are licensed centrally by the European Medicines Agency EMA.
Inform your doctor of any other medical conditions including heart conditions, allergies, pregnancy, or breast-feeding.
It lowers my anxiety. The price is variable and depends on the concentration of drug. The dosage of Anafranil depends on the disease it is being used for and on the severity of the symptoms.
Where can I get more information?
Hepatic impairment Anafranil should be given with caution in patients with hepatic impairment see section 4.
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