Generic Name: Aggrenox
What is Aggrenox?
It is a single product containing 2 medications: aspirin and extended-release dipyridamole. Do not chew capsule. Did you experience many side effects while taking this drug. How likely would you be to recommend Aggrenox to a friend. OverviewUsesBrand NameDrug ClassSide EffectsDrug InteractionsDrug PrecautionsFood InteractionsInform MDPregnancyLactationDrug UsageDrug DosageOverdoseOther RequirementsAggrenox Drug ClassBack to TopAggrenox is part of the drug class:Platelet aggregation inhibitors excl.
See the "Drug Precautions" section. Common side effects of Aggrenox include the following:HeadacheUpset stomachAbdominal painNauseaVomitingDiarrheaFatigueJoint painThis is not a complete list of side effects. Tell your doctor if you have any side effect that bothers you or does not go away.
You may report side effects to the FDA about 1-800-FDA-1088 if window. Aggrenox PrecautionsBack to TopSerious side effects have been reported with Aggrenox, including the following:Bleeding.
Green Tea: Some green tea products contain caffeine. Methylxanthines have been associated with false-negative results during dipyridamole-thallium 201 stress testing.
However, because dipyridamole is a platelet inhibitor and green tea has demonstrated antiplatelet effects in animals, it may be prudent to avoid the concomitant use of green tea with chronic dipyridamole therapy as the risk of bleeding may be increased. Green tea has demonstrated antiplatelet and fibrinolytic actions in animals.
The intranasal H1N1 influenza swine influenza vaccine is contraindicated in children 2 to 17 years of age who are receiving therapy with salicylates e. Reye's syndrome has been associated with aspirin use and wild-type influenza infection.
Heparin: An additive risk of bleeding may be seen in patients receiving platelet inhibitors e. Despite the potential drug-drug interaction between aspirin and heparin, heparin is frequently administered in combination with low-dose aspirin therapy to patients who have had an acute myocardial infarction and in other disease states. Hyaluronidase: Salicylates, when given in large systemic doses, may render tissues partially resistant to the action of hyaluronidase.
Patients receiving these medications may require larger amounts of hyaluronidase for equivalent dispersing effect.
Hydrochlorothiazide, HCTZ: Salicylates can increase the risk of renal toxicity in patients receiving diuretics.
How should I take Aggrenox?
Patients with high frequency hearing loss may have difficulty perceiving tinnitus. In these patients, tinnitus cannot be used as a clinical indicator of salicylismHeart Rate and Rhythm Disorders: Tachycardia, palpitation, arrhythmia, supraventricular tachycardiaLiver and Biliary System Disorders: Cholelithiasis, jaundice, hepatic function abnormalMetabolic and Nutritional Disorders: Hyperglycemia, thirstPlatelet, Bleeding and Clotting Disorders: Hematoma, gingival bleedingPsychiatric Disorders: AgitationReproductive: Uterine hemorrhageRespiratory: Hyperpnea, asthma, bronchospasm, hemoptysis, pulmonary edemaSpecial Senses Other Disorders: Taste lossSkin and Appendages Disorders: Pruritus, urticariaUrogenital: Re The following is a list of additional adverse reactions that have been reported either in the literature or are from post-marketing spontaneous reports for either dipyridamole or aspirin.
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate reliably their frequency or establish a causal relationship to drug exposure. Decisions to include these reactions in labeling are typically based on one or more of the following factors: 1 seriousness of the reaction, 2 frequency of reporting, or 3 strength of causal connection to Aggrenox.
Body as a Whole: Hypothermia, chest painCardiovascular: Angina pectorisCentral Nervous System: Cerebral edemaFluid and Electrolyte: Hyperkalemia, metabolic acidosis, respiratory alkalosis, hypokalemiaGastrointestinal: Pancreatitis, Reye syndrome, hematemesisHearing and Vestibular Disorders: Hearing lossImmune System Disorders: Hypersensitivity, acute anaphylaxis, laryngeal edemaLiver and Biliary System Disorders: Hepatitis, hepatic failureMusculoskeletal: RhabdomyolysisMetabolic and Nutritional Disorders: Hypoglycemia, dehydrationPlatelet, Bleeding and Clotting Disorders: Prolongation of the prothrombin time, disseminated intravascular coagulation, coagulopathy, thrombocytopeniaReproductive: Prolonged pregnancy and labor, stillbirths, lower birth weight infants, antepartum and postpartum bleedingRespiratory: Tachypnea, dyspneaSkin and Appendages Disorders: Rash, alopecia, angioedema, Stevens-Johnson syndrome, skin hemorrhages such as bruising, ecchymosis, and hematomaUrogenital: Interstitial nephritis, papill ary necrosis, proteinuriaVascular Extracardiac Disorders: Allergic vasculitisOther Adverse Events: anorexia, aplastic anemia, migraine, pancytopenia, thrombocytosis.
Adenosine Dipyridamole has been reported to increase the plasma levels and cardiovascular effects of adenosine. Adjustment of adenosine dosage may be necessary. Angiotensin Converting Enzyme ACE Inhibitors Due to the indirect effect of aspirin on the renin-angiotensin conversion pathway, the hyponatremic and hypotensive effects of ACE inhibitors may be diminished by concomitant administration of aspirin.
What should I avoid while taking Aggrenox?
Cyclosporine: Due to the inhibition of renal prostaglandins by salicylates, concurrent use of salicylates and other nephrotoxic agents like cyclosporine may lead to additive nephrotoxicity. Dabigatran: Because dipyridamole is a platelet inhibitor, there is a potential additive risk for bleeding if dipyridamole is given in combination with other agents that affect hemostasis.
Dalteparin: An additive risk of bleeding may be seen in patients receiving a low molecular weight heparin in combination with other agents known to increase the risk of bleeding such as salicylates.
Because dipyridamole is a platelet inhibitor, there is a potential additive risk for bleeding if dipyridamole is given in combination with other agents that affect hemostasis.
Danaparoid: Because dipyridamole is a platelet inhibitor, there is a potential additive risk for bleeding if dipyridamole is given in combination with other agents that affect hemostasis.
Danazol: Danazol can decrease hepatic synthesis of procoagulant factors, increasing the possibility of bleeding when used concurrently with platelet inhibitors. Danazol can decrease hepatic synthesis of procoagulant factors, increasing the possibility of bleeding when used concurrently with platelet inhibitors.
Aggrenox side effects
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication. Alcohol: The risk of stomach bleeding with this medication increases if you have 3 or more alcoholic drinks per day.
Allergy and breathing problems: People who have asthma, long-term breathing problems, or allergic conditions such as hay fever or nasal polyps are more likely to experience difficulty breathing and allergic reactions caused by ASA.
If you have a history of allergic reactions to other substances, or respiratory illness, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Common Aggrenox ide effects may include:
Garlic, Allium sativum: Garlic produces clinically significant antiplatelet effects so additive bleeding may occur if platelet inhibitors are given in combination with garlic.
The antithrombotic action of AGGRENOX is the result of the additive antiplatelet effects of dipyridamole and aspirin.
It is important that you avoid taking Aggrenox if you suffer from severe liver disease.
In the US -Call your doctor for medical advice about side effects.
Internet Stroke CenterExcellent diagrams and information about stroke. Interesting Sites Different StrokesAn online discussion board for those affected by stroke Focusing on younger survivors from the UK GruntDocRamblings of an emergency physician in Texas BrainBlogNews about the brain and behavior. Please leave this field empty. Aggrenox aspirin and extended-release dipyridamole has been approved to reduce the risk of the following conditions in patients:Although Aggrenox decreases the risk of stroke, it does not completely eliminate it.
Where can I get more information?
This restriction typically limits the quantity of the drug that will be covered.
Removal of serum salicylate is also enhanced by hemodialysis.