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This warning came about as a result of various studies on the safety of salmeterol, the bronchodilator portion of the medications. The largest study, called the SMART trial, showed a small increase in the risk of death and hospitalization asthma and breathing problems when taking salmeterol, particularly in African-American patients.
LABAs are not an adequate controller therapy by themselves for asthma, and can potentially cause life-threatening asthma attacks if used alone. This fact has been known for years, just as it is well-known that overuse of albuterol, or any other rescue medication, can place a person at risk for severe asthma attacks, and even death from asthma.
A person with asthma, therefore, should always use an inhaled steroid for treatment of their asthma when a LABA is required. Unfortunately, the SMART trial did not address whether a particular patient was taking an inhaled steroid for their asthma, only if salmeterol was safe by itself in the treatment of asthma.
Most of the patients with the most severe asthma, particularly African-American patients, were not taking an inhaled steroid when placed on the LABA. However, when the study went back and looked at the patients who were taking an inhaled steroid along with the LABA, there did not appear to be an added risk of severe asthma attacks or death from asthma, even in the African-American patients.
Further testing to get to the bottom of the remaining questions was started in 2011 and is expected to be completed in 2011. The FDA states that a LABA medication should not be used if a person with asthma is controlled on an inhaled steroid alone, and should never be the first medication which is prescribed for asthma. If asthma is not controlled on an inhaled steroid, or the level of asthma is classified as being moderate to severe, then combination therapy including an inhaled steroid and a LABA can be a good choice of therapy.
Other treatment choices include increasing the dose of the inhaled steroid or the addition of another medication such as Singulair montelukast or theophylline.
Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes this medication.
If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor. Many of these side effects can be managed, and some may go away on their own over time. Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects. Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Stop taking the medication and seek immediate medical attention if any of the following occur:Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication. Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health.
These factors may affect how you should use this medication. Salmeterol - fluticasone should only be used when a regular inhaled corticosteroid e. If you start developing asthma symptoms, be sure to use your reliever medication for rapid relief of your asthma symptoms. It is very important that you have your reliever medication with you at all times. If you experience worsening symptoms or your reliever medications are not as effective as usual, contact your doctor or seek medical attention immediately.
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You should not use Advair Diskus if you have a severe allergy to milk proteins. Before taking Advair Diskus, tell your doctor about all of your medical conditions. Especially tell your doctor if you:Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.
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In the case of Advair Diskus, there are no specific foods that you must exclude from your diet when receiving this medication.
You should not use Advair Diskus if you have a severe allergy to milk proteins. Before taking Advair Diskus, tell your doctor about all of your medical conditions. Especially tell your doctor if you:Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. The FDA categorizes medications based on safety for use during pregnancy.
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The Salmeterol Multicenter Asthma Research Trial SMART was a randomized double-blind trial that enrolled LABA-naive subjects with asthma to assess the safety of salmeterol 42 mcg twice daily over 28 weeks compared with placebo when added to usual asthma therapy.
The results of the interim analysis showed that subjects receiving salmeterol were at increased risk for fatal asthma events Table 1 and Figure 1. In the total population, a higher rate of asthma-related death occurred in subjects treated with salmeterol than those treated with placebo 0.
Post hoc subpopulation analyses were performed. In Caucasians, asthma-related death occurred at a higher rate in subjects treated with salmeterol than in subjects treated with placebo 0. In African Americans also, asthma-related death occurred at a higher rate in subjects treated with salmeterol than those treated with placebo 0.
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It is also used to prevent or worsening of chronic obstructive pulmonary disease COPD associated with chronic bronchitis.
Regardless of your prescription, it is vital that you report any skin problems, irregular heartbeats or other symptoms that arise to your medical proessional.
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Especially tell your doctor if you take:This is not a complete list of Advair Diskus drug interactions.
Now, the current trend is to use liquid biopsy, which is basically a blood sample. Net provides this medical information service in accordance with these terms and conditions. This site complies with the HONcode standard for trustworthy health information: verify here. Defining patient centricity Guy Yeoman "Putting the patient first in an open and sustained engagement of the patient to respectfully and compassionately achieve the best experience and outcome for that person and their family.
Where can I get more information?
Precautions Do not take Advair Diskus if there is a chance of an allergic reaction to it.
When weighing Advair Diskus vs Advair HFA, a physician must inform you of the potential consequences that apply to both applications.