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Actos is the brand name for the drug pioglitazone also branded as Glustin in Europewhich works to reduce insulin resistance in the liver and surrounding tissue by modifying genes that are otherwise particularly sensitive to insulin. Additionally, it prevents the liver from producing an excess of glucose. It belongs to a group of antidiabetic medications called thiazolidinediones, others being rosiglitazone Avandia. Approved in July 1999, pioglitazone is currently manufactured by pharmaceutical company Takeda under the trade name Actos.

It is available only by prescription of a healthcare provider and is not sold in its generic form. Actos is supplied as tablet containing 15, 30, and 45 mg. Pioglitazone is also available as combination drugs that include Actosplus Met pioglitazone and metforminActoplus Met XR pioglitazone and metformin extended-release formulationand Duetact pioglitazone and glimeperide. Actos UsesActos is mainly prescribed for the treatment of type-2 diabetes together with weight management, regular exercise, healthy diet, smoking reduction, and careful monitoring of blood sugar levels.

This medication may be used alone or in combination with other anti-diabetic drugs belonging to a different drug class, such as metformin Glucophage and insulin.

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Food and Drug Administration FDA is informing the public that use of the diabetes medication Actos pioglitazone for more than one year may be associated with an increased risk of bladder cancer. Information about this risk will be added to the Warnings and Precautions section of the label for pioglitazone-containing medicines.

The patient Medication Guide for these medicines will also be revised to include information on the risk of bladder cancer. The five-year results showed that although there was no overall increased risk of bladder cancer with pioglitazone use, an increased risk of bladder cancer was noted among patients with the longest exposure to pioglitazone, and in those exposed to the highest cumulative dose of pioglitazone. FDA is also aware of a recent epidemiological study conducted in France which suggests an increased risk of bladder cancer with pioglitazone.

Based on the results of this study, France has suspended the use of pioglitazone and Germany has recommended not to start pioglitazone in new patients. To address the long-term risk of bladder cancer associated with pioglitazone use, the drug manufacturer Takeda is conducting a ten-year, observational cohort study as well as a nested case-control study in patients with diabetes who are members of Kaiser Permanente Northern California KPNC health plan.

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The primary efficacy variable was the time to the first occurrence of any event in a cardiovascular composite endpoint that included all-cause mortality, nonfatal myocardial infarction MI including silent MI, stroke, acute coronary syndrome, cardiac intervention including coronary artery bypass grafting or percutaneous intervention, major leg amputation above the ankle, and bypass surgery or revascularization in the leg.

A total of 514 19. Although there was no statistically significant difference between ACTOS and placebo for the three-year incidence of a first event within this composite, there was no increase in mortality or in total macrovascular events with ACTOS.

Edema induced from taking ACTOS is reversible when ACTOS is discontinued. The edema usually does not require hospitalization unless there is coexisting congestive heart failure. A summary of the frequency and types of edema adverse events occurring in clinical investigations of ACTOS is provided in Table 12.

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QUICK LINKS Home Our Firm Client Testimonials Our Victories Our Blog Contact Us Privacy Policy RSS Feed WHAT W A Japanese pharmaceutical company prevailed Thursday in a Las Vegas case involving two women who claimed the diabetes drug Actos caused them to develop bladder cancer.

The lawyers also had planned to seek billions of dollars in punitive damages. Triana and Cipriano sat in the courtroom as the verdict was announced shortly after noon. Both women declined to comment afterward.

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Almost 7,000 patients received Actos in all of the studies combined. The studies measured the level of a substance in the blood called glycosylated haemoglobin HbA1cwhich gives an indication of how well the blood glucose is controlled. Actos on its own was shown to be as effective as metformin and gliclazide.

The most common side effects with Actos seen in between 1 and 10 patients in 100 are upper respiratory tract infection coldshypoaesthesia reduced sense of touchvisual disturbance, bone fractures and increased weight.

If Actos is used in combination with other diabetes medicines, other side effects may occur.

Common Buy Aczone ide effects may include:

  • Over the course of the study, overnight hospitalization for congestive heart failure was reported in 9.

  • Diet Guides NHS diet advice Carbohydrates and diabetes 5:2 diet GI diet Gluten free diet Ketogenic diet Low calorie diets Low carb diet Mediterranean diet Newcastle diet Paleo diet Vegan diet Which foods help diabetes.

  • So how is this prevention.

  • It belongs to a group of antidiabetic medications called thiazolidinediones, others being rosiglitazone Avandia.

CHF is a real but uncommon and preventable risk and MI doesn't seem to be an issue. Cancer risk is very questionable unlike a cancer risk for insulin which seems to be a greater concern.

It is good to have choices, especially when weighing risks and benefits has a degree of uncertainty. Mintz - we still stand firm on two things: 1 these manufacturer self-funded drug studies are questionable to say the least, and 2 knowing what we do about this drug, we would not feel comfortable recommending it to family or friends, esp for a disease they supposedly don't have yet.

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  • But we say skip Actos as both a generic and brand-name medication, unless other options have not worked.

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