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I just wish my Health Insurance hadn't dropped this drug off of it's formulary. You can also take Aciphex with food which I like. The doctor changed the medicine to aciphex and it got worst, to the point that my personality changed completely. Switched to prilosec and still feel very emotional.
Didn't take anything today and stomach is not doing well. Going to try and find some natural type relief. I just stumbled upon this website and I'm shocked.
I was put on a prescription for acid reflux many years back for a feeling of "pressure" under my ribcage.
Hepatic Impairment In a single dose study of 10 patients with mild to moderate hepatic impairment Child-Pugh Class A and B, respectively who were administered a single 20 mg dose of ACIPHEX delayed-release tablets, AUC0-24 was approximately doubled, the elimination half-life was 2-to 3-fold higher, and total body clearance was decreased to less than half compared to values in healthy men.
Drug Interaction Studies Combined Administration With Antimicrobials Sixteen healthy subjects genotyped as extensive metabolizers with respect to CYP2C19 were given 20 mg ACIPHEX delayed-release tablets, 1000 mg amoxicillin, 500 mg clarithromycin, or all 3 drugs in a four-way crossover study. Effects Of Other Drugs On Rabeprazole Antacids: Co-administration of ACIPHEX delayed-release tablets and antacids produced no clinically relevant changes in plasma rabeprazole concentrations.
Effects Of Rabeprazole On Other Drugs Studies in healthy subjects have shown that rabeprazole does not have clinically significant interactions with other drugs metabolized by the CYP450 system, such as theophylline CYP1A2 given as single oral doses, diazepam CYP2C9 and CYP3A4 as a single intravenous dose, and phenytoin CYP2C9 and CYP2C19 given as a single intravenous dose with supplemental oral dosing. Clopidogrel: Clopidogrel is metabolized to its active metabolite in part by CYP2C19.
Cyclosporine: In vitro incubations employing human liver microsomes indicated that rabeprazole inhibited cyclosporine metabolism with an IC50 of 62 micromolar, a concentration that is over 50 times higher than the Cmax in healthy volunteers following 14 days of dosing with 20 mg of ACIPHEX delayed-release tablets. Microbiology The following in vitro data are available but the clinical significance is unknown. Long-Term Maintenance Of Healing Of Erosive Or Ulcerative GERD In Adults The long-term maintenance of healing in patients with erosive or ulcerative GERD previously healed with gastric antisecretory therapy was assessed in two U.
The recommended dosage of ACIPHEX delayed-release tablets is 20 mg once daily for 4 weeks. Healing Of Duodenal Ulcers In Adults In a U. Helicobacter Pylori Eradication In Patients With Peptic Ulcer Disease Or Symptomatic Non-Ulcer Disease In Adults The U.
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The highest tested dose produced a systemic exposure to rabeprazole AUC of 1. Rabeprazole produced gastric enterochromaffin-like ECL cell hyperplasia in male and female rats and ECL cell carcinoid tumors in female rats at all doses including the lowest tested dose.
Its demethylated-metabolite was also positive in the Ames test. Rabeprazole was negative in the in vitro Chinese hamster lung cell chromosome aberration test, the in vivo mouse micronucleus test, and the in vivo and ex vivo rat hepatocyte unscheduled DNA synthesis UDS tests.
There are no available human data on ACIPHEX use in pregnant women to inform the drug associated risk. The background risk of major birth defects and miscarriage for the indicated populations are unknown. Decreased femur length, width and thickness of cortical bone, decreased thickness of the tibial growth plate, and minimal to mild bone marrow hypocellularity were noted at doses of this PPI equal to or greater than 3.
Physeal dysplasia in the femur was also observed in offspring after in utero and lactational exposure to the PPI at doses equal to or greater than 33.
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In May 2010 the FDA warned that PPIs could increase the risk of bone fractures. The warning was in response to several studies that had linked the long-term use of PPIs to an increased risk of bone fractures. If you decide to join this litigation, we may be able to help you seek compensation for your injury, medical expenses, and more. If you or somebody you know was diagnosed with kidney problems, you should contact our lawyers immediately for a free case consultation.
Attention Lawyers: We consider a referral from another law firm to be one of the greatest compliments. Aciphex and Kidney DamageIn December 2014, the FDA updated the label on Aciphex to include stronger warnings about acute interstitial nephritis.
Aciphex and Bone FracturesAciphex and other PPIs may increase the risk of bone fractures - especially fractures of the hip, wrist, or spine - compared to people who do not take PPIs.
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These events have occurred as both new onset and an exacerbation of existing autoimmune disease. Avoid administration of PPIs for longer than medically indicated. If signs or symptoms consistent with CLE or SLE are noted in patients receiving ACIPHEX, discontinue the drug and refer the patient to the appropriate specialist for evaluation.
Most patients improve with discontinuation of the PPI alone in 4 to 12 weeks. ANA may be positive and elevated serological test results may take longer to resolve than clinical manifestations. Daily treatment with any acid-suppressing medications over a long period of time e.
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Atropine: The American College of Gastroenterology states that the effectiveness of proton pump inhibitors PPIs may be theoretically decreased if given with other antisecretory agents e.
Following intravenous administration of 14 C-labeled rabeprazole to lactating rats, radioactivity in milk reached levels that were 2- to 7-fold higher than levels in the blood.
I had NEVER had any problems before that night.
I had an endoscopy two years ago that was pretty normal.
I have not tried that one and you only take it once a day. Did that help to stop your burning throat?. Also what are immune boosters, probiotics and digestive enzymes. I have heard that LPR sufferers need 2 per day-that could very well help more, but I am a bit of a baby about medication and hate taking meds-always prefer the lowest dose possible.
Where can I get more information?
Instruction for using Aciphex Take Aciphex 20mg delayed-release tablet whole and do not break or chew the tablet.
She has taken the Aciphex before with zero issues but this generic is awful.